ArticleNeurology2023
Associations of Dental Health With the Progression of Hippocampal Atrophy in Community-Dwelling Individuals: The Ohasama Study.
Open access · hybridAbstract read
In one paragraph
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Association of periodontitis and tooth loss with cognitive decline in the older adults - a systematic review.BMC oral health · 2026Pooled it
- Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies.BMC oral health · 2026Pooled it
- Periodontal disease and risk of dementia: a systematic review and meta-analysis.Evidence-based dentistry · 2026Article
- Moderating Effects of Oral Bacteria and Tooth Loss on Cognitive Performance.JDR clinical and translational research · 2026Article
- Masticatory Dysfunction and Hippocampal Volume in Ageing Adults: An MRI-Based Scoping Review.Journal of oral rehabilitation · 2026Article
- Longitudinal associations between albuminuria and renal function and annual brain volume changes: the Ohasama study.Clinical and experimental nephrology · 2026Article
- Review
- The DentoNeural Axis: A Piezo channel-mediated mechanosensory pathway linking tooth loss to cognitive decline.Aging brain · 2026Article
- A nomogram model for identifying cognitive frailty in elderly patients with chronic diseases: a multicenter cross-sectional study.Frontiers in public health · 2026Observational
- Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China.Aging clinical and experimental research · 2025Article
- Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases.International dental journal · 2025Article
- Multi-organ frailty is enhanced by periodontitis-induced inflammaging.Inflammation and regeneration · 2025Article
- Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and brain white matter microstructural integrity: the UK Biobank study.Molecular psychiatry · 2025Article
- Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- No genetic causal associations between periodontitis and brain atrophy or cognitive impairment: evidence from a comprehensive bidirectional Mendelian randomization study.BMC oral health · 2024Article
- Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nInnovation (Cambridge (Mass.)) · 2024Article
- Advances in the prevention and treatment of Alzheimer's disease based on oral bacteria.Frontiers in psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 2 institutions in 2 countries.
Satoshi YamaguchiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan. satoshi.yamaguchi.a3@tohoku.ac.jp.ORCID 0000-0001-6423-869X
Takahisa MurakamiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Michihiro SatohFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Takamasa KomiyamaFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Takashi OhiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Yoshitada MiyoshiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Kosei EndoFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Takako HiratsukaFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Azusa HaraFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Yukako TatsumiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Tomoko TotsuneFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Kei AsayamaFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Masahiro KikuyaFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.ORCID 0000-0002-3080-6107
Kyoko NomuraFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Atsushi HozawaFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Hirohito MetokiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.ORCID 0000-0002-1894-3328
Yutaka ImaiFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Makoto WatanabeFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Takayoshi OhkuboFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Yoshinori HattoriFrom the Division of Aging and Geriatric Dentistry (S.Y., T.M., T.K., T. Ohi, Y.M., K.E., T.H., Y.H.), Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry; Division of Public Health, Hygiene and Epidemiology (T.M., M.S., H.M.), Faculty of Medicine, Tohoku Medical and Pharmaceutical University; Department of Preventive Medicine and Epidemiology (T.M., M.S., M.K., A. Hozawa, H.M.), Tohoku Medical Megabank Organization, Tohoku University, Sendai; Japanese Red Cross Ishinomaki Hospital (T. Ohi); Division of Drug Development and Regulatory Science (A. Hara), Faculty of Pharmacy, Keio University; Department of Hygiene and Public Health (Y.T., K.A., M.K., T. Ohkubo), Teikyo University School of Medicine, Tokyo; Department of Neurology (T.T.), National Hospital Organization Sendai Nishitaga Hospital; Department of Aging Research and Geriatric Medicine (T.T.), Institute of Development, Aging and Cancer, Tohoku University; Tohoku Institute for Management of Blood Pressure (K.A., H.M., Y.I., T. Ohkubo), Sendai, Miyagi; Department of Environmental Health Science and Public Health (K.N.), Akita University Graduate School of Medicine; and Research Institute of Living and Environmental Sciences (M.W.), Miyagi Gakuin Women's University, Sendai, Japan.
Tamil Nadu Dr. M.G.R. Medical University · INTohoku University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesAlthough tooth loss and periodontitis have been considered risk factors of Alzheimer disease, recent longitudinal researches have not found a significant association with hippocampal atrophy. Therefore, this study aimed to clarify a longitudinal association between the number of teeth present (NTP) and hippocampal atrophy dependent on the severity of periodontitis in a late middle-aged and older adult population.
methodsThis study included community-dwelling individuals aged 55 years or older who had no cognitive decline and had undergone brain MRI and oral and systemic data collection twice at 4-year intervals. Hippocampal volumes were obtained from MRIs by automated region-of-interest analysis. The mean periodontal probing depth (PD) was used as a measure of periodontitis. Multiple regression analysis was performed with the annual symmetric percentage change (SPC) of the hippocampal volume as the dependent variable and including an interaction term between NTP and mean PD as the independent variable. The interaction details were examined using the Johnson-Neyman technique and simple slope analysis. The 3-way interaction of NTP, mean PD, and time on hippocampal volume was analyzed using a linear mixed-effects model, and the interaction of NTP and time was examined in subgroups divided by the median mean PD. In all models, dropout bias was adjusted by inverse probability weighting.
resultsData of 172 participants were analyzed. The qualitative interaction between NTP and the mean PD was significant for the annual SPC in the left hippocampus. The regression coefficient of the NTP on the annual SPC in the left hippocampus was positive ( DISCUSSION: In a late middle-aged and older cohort, fewer teeth were associated with a faster rate of left hippocampal atrophy in patients with mild periodontitis, whereas having more teeth was associated with a faster rate of atrophy in those with severe periodontitis. The importance of keeping teeth healthy is suggested.
Indexed as
Alzheimer DiseasePeriodontitisAgedAtrophyHippocampusHumansIndependent LivingLongitudinal StudiesMagnetic Resonance ImagingMiddle Aged
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