ArticleNeurology2023
Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias.
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Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults.Neurology · 2025Trial
- The influence of blood lipids on cerebral perfusion by apolipoprotein E status.Journal of lipid research · 2026Article
- Vascular risk factor variability and cognitive impairment in older adults a community-based retrospective study.Scientific reports · 2025Article
- Retarded Learning in a Rabbit Model of Metabolic Syndrome Created by Long-Term Feeding of High-Fat Diet and High Sucrose.Nutrients · 2025Article
- The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation.Scientific reports · 2025Article
- Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project.Archives of gerontology and geriatrics · 2025Article
- Response to "Comment on 'Independent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias' ".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lipid Trajectories Improve Risk Models for Alzheimer's Disease and Mild Cognitive Impairment.medRxiv : the preprint server for health sciences · 2024Article
- Temporal Characterization of the Amyloidogenic APPswe/PS1dE9;hAPOE4 Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2024Article
- The "Hit and Run" Hypothesis for Alzheimer's Disease Pathogenesis.International journal of molecular sciences · 2024Article
- Cognitive function in dyslipidemia patients: exploring the impact of statins.Frontiers in neurology · 2024Article
- Gut microbiota in combination with blood metabolites reveals characteristics of the disease cluster of coronary artery disease and cognitive impairment: a Mendelian randomization study.Frontiers in immunology · 2023Article
- Melanin: a unifying theory of disease as exemplified by Parkinson's, Alzheimer's, and Lewy body dementia.Frontiers in immunology · 2023Article
- Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings.Journal of Alzheimer's disease reportsReview
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Authors and funding
13 authors at 1 institution in 1 country.
Ethan D MoserFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-1094-9108
Sheila M ManemannFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Nicholas B LarsonFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-3468-4215
Jennifer L St SauverFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Paul Y TakahashiFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Michelle M MielkeFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-7177-1185
Walter A RoccaFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Janet E OlsonFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Véronique L RogerFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Alan T RemaleyFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-2473-5549
Paul A DeckerFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Jill M KillianFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Suzette J BielinskiFrom the Department of Quantitative Health Sciences (E.D.M., S.M.M., N.B.L., J.L.S.S., M.M.M., W.A.R., J.E.O., V.L.R., P.A.D., J.M.K., S.J.B.); Division of Community Internal Medicine (P.Y.T.), Department of Medicine, Mayo Clinic; Department of Neurology (M.M.M., W.A.R.), Rochester, MN; Department of Epidemiology and Prevention (M.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Mayo Clinic Women's Health Research Center (W.A.R.); Department of Cardiovascular Medicine (V.L.R.), Mayo Clinic, Rochester, MN; Epidemiology and Community Branch (V.L.R.), National Heart, Lung, and Blood Institute, National Institutes of Health; and Lipoprotein Metabolism Laboratory (A.T.R.), Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. bielinski.suzette@mayo.edu.ORCID 0000-0002-2905-5430
National Institutes of Health · US
Funding
Harnessing the Electronic Health Record to Predict Risk of Cardiovascular DiseaseR01HL136659 · NHLBI · MAYO CLINIC ROCHESTER · PI BIELINSKI, SUZETTE JANINE · 2018 to 2021
$3.2MInterdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4MInterdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437kNHLBI NIH HHS R01 HL136659NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738
Abstract
BACKGROUND AND
objectivesPrevention strategies for Alzheimer disease and Alzheimer disease-related dementias (AD/ADRDs) are urgently needed. Lipid variability, or fluctuations in blood lipid levels at different points in time, has not been examined extensively and may contribute to the risk of AD/ADRD. Lipid panels are a part of routine screening in clinical practice and routinely available in electronic health records (EHR). Thus, in a large geographically defined population-based cohort, we investigated the variation of multiple lipid types and their association to the development of AD/ADRD.
methodsAll residents living in Olmsted County, Minnesota on the index date January 1, 2006, aged 60 years or older without an AD/ADRD diagnosis were identified. Persons with ≥3 lipid measurements including total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), or high-density lipoprotein cholesterol (HDL-C) in the 5 years before index date were included. Lipid variation was defined as any change in individual's lipid levels over time regardless of direction and was measured using variability independent of the mean (VIM). Associations between lipid variation quintiles and incident AD/ADRD were assessed using Cox proportional hazards regression. Participants were followed through 2018 for incident AD/ADRD.
resultsThe final analysis included 11,571 participants (mean age 71 years; 54% female). Median follow-up was 12.9 years with 2,473 incident AD/ADRD cases. After adjustment for confounding variables including sex, race, baseline lipid measurements, education, BMI, and lipid-lowering treatment, participants in the highest quintile of total cholesterol variability had a 19% increased risk of incident AD/ADRD, and those in highest quintile of triglycerides, variability had a 23% increased risk. DISCUSSION: In a large EHR derived cohort, those in the highest quintile of variability for total cholesterol and triglyceride levels had an increased risk of incident AD/ADRD. Further studies to identify the mechanisms behind this association are needed.
Indexed as
Alzheimer DiseaseAgedCholesterol, HDLCholesterol, LDLFemaleHumansMaleMinnesotaTriglyceridesCholesterol, HDLCholesterol, LDLTriglycerides
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