Evidence map›Paper›PMID 37407243›Full record

ArticleInfection & chemotherapy2023

Feasibility of Using Bacteriophage Therapy to Reduce Morbidity and Mortality Associated with Spinal Epidural Abscesses.

James B Doub, Jeremy Tran, Ryan Smith, Tyler Pease, Eugene Koh, Stephen Ludwig, Alina Lee, Ben Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection & chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James B DoubDivision of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, USA. Jdoub@ihv.umaryland.edu.ORCID https://orcid.org/0000-0002-4977-0968
Jeremy TranWalter Reed National Military Medical Center, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-6558-6327
Ryan SmithDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-9006-4347
Tyler PeaseDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-0372-9270
Eugene KohDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-7905-1761
Stephen LudwigDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-1857-6203
Alina LeeYale Center for Phage Biology & Therapy, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-3364-4780
Ben ChanYale Center for Phage Biology & Therapy, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-9436-3694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the feasibility of using bacteriophage therapeutics in spinal epidural abscess (SEA) by reviewing the causes and outcomes of SEA at a single institution and testing a bacteriophage for activity against preserved SEA clinical isolates. MATERIALS AND

methodsMedical records were reviewed of patients that received incision and drainage for SEA at a single medical center. Causative organisms, incidence of coinciding bacteremia and outcomes were recorded. A subset of SEA patients (N = 11), that had preserved clinical isolates, were assessed to evaluate if a bacteriophage therapeutic had ample activity to those isolates as seen with spot tests and growth inhibition assays.

results

conclusionSEA is associated with significant mortality and morbidity making this a potential indication for adjuvant bacteriophage therapeutics. Since

Indexed as

BacteremiaBacteriophage therapySpinal epidural abscessStaphylococcus aureus

Identifiers

PMID37407243
PMCPMC10323537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.