Evidence map›Paper›PMID 37407076›Full record

ArticleBMJ (Clinical research ed.)2023

Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.

Harrison Wilde, Christopher Tomlinson, Bilal A Mateen, David Selby, Hari Krishnan Kanthimathinathan, Padmanabhan Ramnarayan, Pascale Du Pre, Mae Johnson, Nazima Pathan, Arturo Gonzalez-Izquierdo and 7 more

Open access · hybridAbstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Vaccination in pregnancy to protect the newborn.Nature reviews. Immunology · 2025
    Review
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  7. Misattribution Bias of COVID-19 Hospitalizations in Alberta Using an Admission Algorithm.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 3 countries.

Harrison WildeDepartment of Statistics, University of Warwick, Warwick, UK.
Christopher TomlinsonUniversity College London (UCL) Institute of Health Informatics, UCL, London, UK.
Bilal A MateenUniversity College London (UCL) Institute of Health Informatics, UCL, London, UK.
David SelbyDepartment for Data Science and its Applications, German Research Centre for Artificial Intelligence (DFKI), Kaiserslautern, Germany.
Hari Krishnan KanthimathinathanPaediatric Intensive Care Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Padmanabhan RamnarayanDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London UK Imperial College London, London, UK.
Pascale Du PreBiomedical Research Centre, Great Ormond Street Hospital for Children, London, UK.
Mae JohnsonBiomedical Research Centre, Great Ormond Street Hospital for Children, London, UK.
Nazima PathanUniversity Department of Paediatrics, Cambridge University, Cambridge, UK.
Arturo Gonzalez-IzquierdoUniversity College London (UCL) Institute of Health Informatics, UCL, London, UK.
Alvina G LaiUniversity College London (UCL) Institute of Health Informatics, UCL, London, UK.
Deepti GurdasaniWilliam Harvey Institute, Queen Mary University of London, London, UK.
Christina PagelClinical Operational Research Unit, UCL, London, UK.
Spiros DenaxasUniversity College London (UCL) Institute of Health Informatics, UCL, London, UK.
Sebastian VollmerDepartment for Data Science and its Applications, German Research Centre for Artificial Intelligence (DFKI), Kaiserslautern, Germany.
Katherine BrownInstitute of Cardiovascular Science, UCL, London, UK sejjklb@ucl.ac.uk.ORCID 0000-0002-0729-4959
CVD-COVID-UK/COVID-IMPACT consortium
Great Ormond Street Hospital · GBUCL Biomedical Research Centre · GBUniversity College London · GBUniversity of Kaiserslautern · DEBirmingham Women’s and Children’s NHS Foundation Trust · GBImperial College London · GBQueen Mary University of London · GBUK Research and Innovation · GBUniversity College Hospital · GBUniversity of Cambridge · GBUniversity of Warwick · GB

Funding

Medical Research Council MC_PC_20030Medical Research Council MC_PC_20051Medical Research Council MC_PC_20058Medical Research Council MC_PC_20059
6 · The paper itself

Abstract

objectiveTo describe hospital admissions associated with SARS-CoV-2 infection in children and adolescents.

designCohort study of 3.2 million first ascertained SARS-CoV-2 infections using electronic health care record data.

settingEngland, July 2020 to February 2022.

participantsAbout 12 million children and adolescents (age <18 years) who were resident in England.

main outcome measuresAscertainment of a first SARS-CoV-2 associated hospital admissions: due to SARS-CoV-2, with SARS-CoV-2 as a contributory factor, incidental to SARS-CoV-2 infection, and hospital acquired SARS-CoV-2.

results3 226 535 children and adolescents had a recorded first SARS-CoV-2 infection during the observation period, and 29 230 (0.9%) infections involved a SARS-CoV-2 associated hospital admission. The median length of stay was 2 (interquartile range 1-4) days) and 1710 of 29 230 (5.9%) SARS-CoV-2 associated admissions involved paediatric critical care. 70 deaths occurred in which covid-19 or paediatric inflammatory multisystem syndrome was listed as a cause, of which 55 (78.6%) were in participants with a SARS-CoV-2 associated hospital admission. SARS-CoV-2 was the cause or a contributory factor in 21 000 of 29 230 (71.8%) participants who were admitted to hospital and only 380 (1.3%) participants acquired infection as an inpatient and 7855 (26.9%) participants were admitted with incidental SARS-CoV-2 infection. Boys, younger children (<5 years), and those from ethnic minority groups or areas of high deprivation were more likely to be admitted to hospital (all P<0.001). The covid-19 vaccination programme in England has identified certain conditions as representing a higher risk of admission to hospital with SARS-CoV-2: 11 085 (37.9%) of participants admitted to hospital had evidence of such a condition, and a further 4765 (16.3%) of participants admitted to hospital had a medical or developmental health condition not included in the vaccination programme's list.

conclusionsMost SARS-CoV-2 associated hospital admissions in children and adolescents in England were due to SARS-CoV-2 or SARS-CoV-2 was a contributory factor. These results should inform future public health initiatives and research.

Indexed as

COVID-19AdolescentChildCohort StudiesCOVID-19 VaccinesEnglandEthnicityHospitalsHumansMaleMinority GroupsSARS-CoV-2Systemic Inflammatory Response SyndromeCOVID-19 Vaccines

Identifiers

PMID37407076
PMCPMC10318942
OpenAlexW4383265009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.