Evidence map›Paper›PMID 37407053›Full record

ArticleBMJ open2023

Resective Epilepsy Surgery, QUality of life and Economic evaluation (RESQUE): the change in quality of life after resective epilepsy surgery-protocol for a multicentre, prospective cohort study.

Julia T F Kellenaers, Kim Rijkers, Ghislaine A P G van Mastrigt, Olaf E M G Schijns, Govert Hoogland, Jim Dings, Sander van Kuijk, Marielle C G Vlooswijk, Louis G L Wagner, Sander Idema and 3 more

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julia T F KellenaersDepartment of Neurosurgery, Maastricht University Medical Centre+, Maastricht, The Netherlands julia.kellenaers@mumc.nl.ORCID 0000-0003-3655-4737
Kim RijkersDepartment of Neurosurgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Ghislaine A P G van MastrigtDepartment of Health Services Research, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-8053-5512
Olaf E M G SchijnsDepartment of Neurosurgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Govert HooglandDepartment of Neurosurgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Jim DingsDepartment of Neurosurgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Sander van KuijkClinical Epidemiology and Medical Technology Assessment, Maastricht Universitair Medisch Centrum+, Maastricht, The Netherlands.ORCID 0000-0003-2796-729X
Marielle C G VlooswijkMaastricht Universitair Medisch Centrum+, Maastricht, The Netherlands.
Louis G L WagnerKempenhaeghe Epilepsy Centre, Heeze, The Netherlands.
Sander IdemaDepartment of Neurosurgery, Amsterdam UMC VUMC Site, Amsterdam, The Netherlands.
Ilse E C W van StraatenDepartment of Neurology, Amsterdam UMC VUMC Site, Amsterdam, The Netherlands.
Sandra M A van der SalmDepartment of Neurology, University Medical Centre Utrecht Brain Centre, Utrecht, The Netherlands.
Marian H J M MajoieKempenhaeghe Epilepsy Centre, Heeze, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResective epilepsy surgery is often seen as a last resort when treating drug-resistant epilepsy. Positive results on quality of life (QoL) and economic benefits after surgery argue for a less restrictive attitude towards epilepsy surgery for drug-resistant epilepsy. QoL and economic benefits are country-dependent. The objective of the Resective Epilepsy Surgery, QUality of life and Economic evaluation (RESQUE) trial is to evaluate the change in QoL before and after epilepsy surgery in Dutch people with drug-resistant epilepsy. The results will form part of an economic evaluation of epilepsy surgery in people with epilepsy (PWE) in The Netherlands. METHODS AND ANALYSIS: A longitudinal prospective multicentre cohort study involving 100 PWE undergoing epilepsy surgery between 2019 and 2025 is being performed in three Dutch academic hospitals. Excluded are PWE who have a lower level of intelligence (TIQ<70) or who do not master the Dutch language. Before surgery and 3, 6, 12 and 24 months after surgery, PWE receive validated online questionnaires (QOLIE-31, EQ-5D, iMCQ and iPCQ) on QoL, cost of care, expectations and satisfaction. Primary outcome is the change in QoL. Secondary outcomes are change in generic QoL, seizure reduction (International League Against Epilepsy Outcome Classification), medical consumption, productivity, the correlation between QoL and seizure reduction and expectation of and satisfaction with the surgery. ETHICS AND DISSEMINATION: The study design has been approved by the Medical Ethics Review Committee (METC) of Maastricht UMC+ (2019-1134) and the Amsterdam UMC (vu). At the time of writing, UMC Utrecht is in the process of considering approval. The study will be conducted according to the Dutch Medical Research Involving Human Subjects Act and the Declaration of Helsinki. The results will be publicly disclosed and submitted for publication in international peer-reviewed scientific journals. There is no veto on publication by the involved parties.

trial registrationNL8278; Pre-results.

Indexed as

Drug Resistant EpilepsyEpilepsyCohort StudiesCost-Benefit AnalysisHumansMulticenter Studies as TopicProspective StudiesQuality of LifeSeizuresTreatment Outcomeepilepsyneurosurgerysurgery

Identifiers

PMID37407053
PMCPMC10335478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.