ArticleBMJ open2023
Bidirectional association between depressive symptoms and cardiovascular disease in the middle-aged and elderly Chinese: a 5-year longitudinal study.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Association between atherogenic index of plasma and depression risk: a meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Association Between Depressive Symptoms and Risk of New-Onset Chronic Liver Disease Among Middle-Aged and Elderly Chinese Adults: A Prospective Cohort Study Based on the China Health and Retirement Longitudinal Study.Healthcare (Basel, Switzerland) · 2026Article
- Association of longitudinal changes in depressive symptoms and handgrip strength with cardiovascular disease in middle-aged and elderly populations.BMC public health · 2026Article
- The interplay of multimorbidity and depressive symptoms: mediation role of functional dependence.Epidemiology and psychiatric sciences · 2026Article
- BDNF mediates the heart-brain axis: implications for cardiovascular diseases and mental disorders.European archives of psychiatry and clinical neuroscience · 2026Review
- Dissecting Depression in Cardiovascular Disease in Middle-Aged and Older Adults: Evidence That Comorbidity is Associated with Higher Depression Network Strength.Psychology research and behavior management · 2026Article
- How are chronic diseases related to depressive symptoms in older adults? The role of life satisfaction and multidimensional intergenerational relationships.BMC geriatrics · 2025Article
- Impact of second victim experience and support and psychological empowerment on depressive symptoms among nurses in China -a latent class analysis.BMC psychology · 2025Article
- Multimorbidity Patterns and Depression: Bridging Epidemiological Associations with Predictive Analytics for Risk Stratification.Healthcare (Basel, Switzerland) · 2025Article
- Network analysis of anxiety and depressive symptoms among patients with cardiovascular disease.BMC public health · 2025Article
- Screening Depression in Ischemic Heart Disease: Gender Differences and Psychosocial Implications Using a Self-Developed Questionnaire.Journal of clinical medicine · 2025Article
- Association Between Geriatric Oral Health Assessment Index and Cardiovascular Disease in Korean Older Adults.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Comparing the Association Between Depressive Symptoms and Cardiovascular Disease Among the Middle-Aged and Elderly Population: A National Survey of 9,049 Subjects Based on the Indonesian Family Life Survey-5.Vascular health and risk management · 2025Article
- An Updated Review on the Complex Association of Cardiovascular Disease (CVD) and Depression.Current cardiology reviews · 2025Review
- Association between cardiorenal syndrome and depressive symptoms among the US population: a mediation analysis via lipid indices.Lipids in health and disease · 2024Article
- Association of combined body mass index and central obesity with cardiovascular disease in middle-aged and older adults: a population-based prospective cohort study.BMC cardiovascular disorders · 2024Article
- The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review.Life (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDepressive symptoms and cardiovascular diseases (CVDs) are important issues affecting the health of the middle-aged and elderly population in China. This study aimed to investigate the bidirectional association between depressive symptoms and CVD in middle-aged and elderly people in China.
designA 5-year longitudinal study. SETTING AND
participantsWe included 6702 middle-aged and elderly participants from China Health and Retirement Longitudinal Study (CHARLS), which is a nationwide longitudinal household survey that started in 2011 (T1) and followed up every 2 years in 2013 (T2) and 2015 (T3). OUTCOME MEASURES: Depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale. Binary logistic regression was used to identify the influencing factors of depressive symptoms and CVD at T1. The cross-lagged panel model was used to analyse the association between depressive symptoms and CVD at T1, T2 and T3.
resultsThe CHARLS is a representative longitudinal survey of people aged ≥45 years. Using data extracted from the CHARLS, overall, at T1, 2621 (39.10%) participants had depressive symptoms and 432 (6.4%) had CVD, and at T3, 2423 (36.2%) had depressive symptoms and 760 (11.3%) had CVD, respectively. Depressive symptoms at T1 had a effect on CVD at T2 (β=0.015, p=0.009), and depressive symptoms at T2 had an effect on CVD at T3 (β=0.015, p=0.034). CVD at T1 predicted depressive symptoms at T2 (β=0.036, p=0.002).
conclusionsThere is a bidirectional predictive effect between depressive symptoms and CVD. The effect of depressive symptoms on CVD is stable, and CVD has an effect on depressive symptoms in a short period of time.
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