Evidence map›Paper›PMID 37407030›Full record

ArticleAdvanced healthcare materials2023

A Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early.

Nate T Garland, Joseph W Song, Tengfei Ma, Yong Jae Kim, Abraham Vázquez-Guardado, Ayemeh Bagheri Hashkavayi, Sankalp Koduvayur Ganeshan, Nivesh Sharma, Hanjun Ryu, Min-Kyu Lee and 9 more

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
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  6. Review
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  8. Article
  9. Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025
    Article
  10. Article
  11. Smart Dust for Chemical Mapping.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Use of Wireless Smart Devices in Remote Monitoring of Chronic Wounds: A Scoping Review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nate T GarlandDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA.
Joseph W SongDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Tengfei MaIBM T. J. Watson Research Center, Ossining, NY, 10562, USA.
Yong Jae KimDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA.
Abraham Vázquez-GuardadoQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60611, USA.
Ayemeh Bagheri HashkavayiDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA.
Sankalp Koduvayur GaneshanCenter for Advanced Self-Powered Systems of Integrated Sensors and Technologies(ASSIST), North Carolina State University, Raleigh, NC, 27606, USA.
Nivesh SharmaDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA.
Hanjun RyuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60611, USA.
Min-Kyu LeeQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60611, USA.
Brandon SumpioJoslin-Beth Israel Deaconess Foot Center and the Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Margaret A JakusDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Viviane ForsbergQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60611, USA.
Rajaram KavetiDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA.
Samuel K SiaDepartment of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Aristidis VevesJoslin-Beth Israel Deaconess Foot Center and the Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
John A RogersDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Guillermo A AmeerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Amay J BandodkarDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA.ORCID 0000-0002-1792-1506

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Telemetric Regenerative Bandage for Accelerating Wound HealingR01DK131302 · NIDDK · NORTHWESTERN UNIVERSITY · PI AMEER, GUILLERMO ANTONIO, ROGERS, JOHN · 2021 to 2025
$3.2M
NCI NIH HHS P30 CA060553NIDDK NIH HHS R01 DK131302
6 · The paper itself

Abstract

Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free wound monitor that measures lactate in real-time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 days post-injury with ≈76% accuracy, which increases to ≈83% when pH is included. These studies underscore the significance of monitoring biomarkers during the inflammation phase, which can offer several benefits, including short-term use of wound monitors and their easy removal, resulting in lower risks of injury and infection at the wound site. Improvements in prediction accuracy can be achieved by designing mathematical models that build on multiple wound parameters such as pro-inflammatory and metabolic markers. Achieving this goal will require designing multi-analyte wound monitors.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic FootAnimalsBandagesLactatesMiceWound HealingLactateschronic woundsdiabetic ulcerslactate sensingwireless electronicswound sensing

Identifiers

PMID37407030
PMCPMC10766868

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.