Evidence map›Paper›PMID 37406760›Full record

Trial reportResuscitation2023

Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial.

Ryan W Morgan, Ron W Reeder, Tageldin Ahmed, Michael J Bell, John T Berger, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A Carcillo, Todd C Carpenter and 37 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Resuscitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837497 (Improving Outcomes After Pediatric Cardiac Arrest), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02837497 nacompletednot on this map

Improving Outcomes After Pediatric Cardiac Arrest

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2016 to 2021Enrolled1,127ConditionsCardiac ArrestArmsICU-RESUS CPR Improvement Bundle
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

47 authors at 14 institutions in 1 country.

Ryan W MorganDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: MorganR1@chop.edu.
Ron W ReederDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Tageldin AhmedDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA.
Michael J BellDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
John T BergerDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
Robert BishopDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Matthew BochkorisDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Candice BurnsDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, USA.
Joseph A CarcilloDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Todd C CarpenterDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
J Michael DeanDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
J Wesley DiddleDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
Myke FedermanDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, USA.
Richard FernandezDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Ericka L FinkDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Deborah FranzonDepartment of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, USA.
Aisha H FrazierNemours Cardiac Center, Nemours Children's Health, Delaware and Thomas Jefferson University, Wilmington, DE, USA; Department of Pediatrics, Nemours Children's Health, Delaware and Thomas Jefferson University, Wilmington, DE, USA.
Stuart H FriessDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Kathryn GrahamDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Mark HallDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
David A HehirDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Adam S HimebauchDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Christopher M HorvatDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Leanna L HuardDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, USA.
Tensing MaaDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Arushi MangaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Patrick S McQuillenDepartment of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, USA.
Kathleen L MeertDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA.
Peter M MouraniDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR, USA.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Maryam Y NaimDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Daniel NottermanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Kent PageDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Murray M PollackDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
Anil SapruDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, USA.
Carleen SchneiterDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Matthew P SharronDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
Neeraj SrivastavaDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, USA.
Sarah TabbuttDepartment of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, USA.
Bradley TilfordDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA.
Shirley ViteriDepartment of Pediatrics, Nemours Children's Health, Delaware and Thomas Jefferson University, Wilmington, DE, USA.
David WesselDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
Heather A WolfeDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Andrew R YatesDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Athena F ZuppaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Robert A BergDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Robert M SuttonDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USGeorge Washington University · USNationwide Children's Hospital · USUniversity of California, Los Angeles · USUniversity of Pittsburgh · USCentral Michigan University · USChildren's Hospital Colorado · USUniversity of California, San Francisco · USUniversity of Utah · USThomas Jefferson University · USWashington University in St. Louis · USArkansas Children's Hospital · USMichigan State University · USPrinceton University · US

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
CPCCRN PRECISE SupplementPL1HD105462 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jonathan Michael Dean · 2021 to 2026
$17.5M
Improving Outcomes after Pediatric Cardiac ArrestR01HL131544 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI SUTTON, ROBERT MICHAEL · 2016 to 2020
$3.9M
Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7M
Collaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5M
Collaborative Pediatric Critical Care Research Network (UG1)UG1HD083170 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2015 to 2020
$1.5M
Validation of Physiologic CPR Quality Using NOn-inVasive Waveform Analytics (CPR-NOVA)R01HL147616 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, SUTTON, ROBERT MICHAEL · 2019 to 2021
$1.2M
The Roles of Pulmonary Hypertension and Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress SyndromeK23HL153759 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI HIMEBAUCH, ADAM S. · 2021 to 2025
$879k
NHLBI NIH HHS K23 HL148541NHLBI NIH HHS K23 HL153759NHLBI NIH HHS R01 HL131544NHLBI NIH HHS R01 HL147616NICHD NIH HHS PL1 HD105462NICHD NIH HHS U01 HD049934NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171
6 · The paper itself

Abstract

backgroundPrevious studies have identified pulmonary hypertension (PH) as a relatively common diagnosis in children with in-hospital cardiac arrest (IHCA), and preclinical laboratory studies have found poor outcomes and low systemic blood pressures during CPR for PH-associated cardiac arrest. The objective of this study was to determine the prevalence of PH among children with IHCA and the association between PH diagnosis and intra-arrest physiology and survival outcomes.

methodsThis was a prospectively designed secondary analysis of patients enrolled in the ICU-RESUS clinical trial (NCT02837497). The primary exposure was a pre-arrest diagnosis of PH. The primary survival outcome was survival to hospital discharge with favorable neurologic outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged from baseline). The primary physiologic outcome was event-level average diastolic blood pressure (DBP) during CPR.

resultsOf 1276 patients with IHCAs during the study period, 1129 index IHCAs were enrolled; 184 (16.3%) had PH and 101/184 (54.9%) were receiving inhaled nitric oxide at the time of IHCA. Survival with favorable neurologic outcome was similar between patients with and without PH on univariate (48.9% vs. 54.4%; p = 0.17) and multivariate analyses (aOR 0.82 [95%CI: 0.56, 1.20]; p = 0.32). There were no significant differences in CPR event outcome or survival to hospital discharge. Average DBP, systolic BP, and end-tidal carbon dioxide during CPR were similar between groups.

conclusionsIn this prospective study of pediatric IHCA, pre-existing PH was present in 16% of children. Pre-arrest PH diagnosis was not associated with statistically significant differences in survival outcomes or intra-arrest physiologic measures.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestHypertension, PulmonaryChildHumansIntensive Care UnitsProspective StudiesBlood pressureCardiac arrestCardiopulmonary resuscitationPediatricsPulmonary hypertension

Identifiers

PMID37406760
PMCPMC10530491
OpenAlexW4382933244

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.