Evidence map›Paper›PMID 37406367›Full record

ArticlePsychiatry research2023

Mismatch negativity predicts initial auditory-based targeted cognitive training performance in a heterogeneous population across psychiatric disorders.

Yash B Joshi, Christopher E Gonzalez, Juan L Molina, Laura R MacDonald, Jenny Min Din, Jessica Minhas, Taylor Leposke, Bethany Nordberg, Francesca Li, Jo Talledo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yash B JoshiVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA. Electronic address: yajoshi@health.ucsd.edu.
Christopher E GonzalezVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
Juan L MolinaVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
Laura R MacDonaldUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA, USA.
Jenny Min DinUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA, USA.
Jessica MinhasUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA, USA.
Taylor LeposkeUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA, USA.
Bethany NordbergUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA, USA.
Francesca LiUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA, USA.
Jo TalledoVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
Joyce SprockVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
Neal R SwerdlowVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
Gregory A LightVA San Diego Healthcare System, La Jolla, CA, USA; University of California, San Diego, Department of Psychiatry, La Jolla, CA, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.

Funding

Pharmacologic augmentation of targeted cognitive training in schizophreniaR33MH123603 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2020 to 2022
$2.3M
Memantine augmentation of cognitive training in schizophreniaR33MH125114 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIGHT, GREGORY A · 2021 to 2023
$2.2M
Biomarker Predictors of Memantine Sensitivity in patients with Alzheimer's DiseaseR01AG059640 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2018 to 2022
$2.0M
NIA NIH HHS R01 AG059640NIMH NIH HHS R33 MH123603NIMH NIH HHS R33 MH125114RRD VA IK1 RX003683RRD VA IK2 RX003395
6 · The paper itself

Abstract

Auditory-based targeted cognitive training (ATCT) programs are emerging pro-cognitive therapeutic interventions which aim to improve auditory processing to attenuate cognitive impairment in a "bottom up" manner. Biomarkers of early auditory information processing (EAIP) like mismatch negativity (MMN) and P3a have been used successfully to predict gains from a full 40 h course of ATCT in schizophrenia (SZ). Here we investigated the ability of EAIP biomarkers to predict ATCT performance in a group of subjects (n = 26) across SZ, MDD, PTSD and GAD diagnoses. Cognition was assessed via the MATRICS Consensus Cognitive Battery (MCCB) and MMN/P3a were collected prior to completing 1 h of "Sound Sweeps," a representative ATCT exercise. Baseline and final performance over the first two levels of cognitive training served as the primary dependent variables. Groups had similar MMN, but the SZ group had attenuated P3a. MMN and MCCB cognitive domain t-scores, but not P3a, were strongly correlated with most ATCT performance measures, and explained up to 61% of variance in ATCT performance. Diagnosis was not a significant predictor for ATCT performance. These data suggest that MMN can predict ATCT performance in heterogeneous neuropsychiatric populations and should be considered in ATCT studies across diagnostically diverse cohorts.

Indexed as

Cognitive DysfunctionSchizophreniaAcoustic StimulationAuditory PerceptionCognitive TrainingElectroencephalographyEvoked Potentials, AuditoryHumansCognitive trainingGADNeurophysiologyPTSDSchizophreniaTransdiagnostic

Identifiers

PMID37406367
PMCPMC13250892

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.