Evidence map›Paper›PMID 37406301›Full record

ArticleMolecular pharmaceutics2023

Impact of Propeptide Cleavage on the Stability and Activity of a Streptococcal Immunomodulatory C5a Peptidase for Biopharmaceutical Development.

Vinayakumar Gedi, Francisco Duarte, Pratikkumar Patel, Promita Bhattacharjee, Malgorzata Tecza, Kieran McGourty, Sarah P Hudson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vinayakumar GediDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Francisco DuarteDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID 0000-0001-7550-9504
Pratikkumar PatelDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Promita BhattacharjeeDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Malgorzata TeczaDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Kieran McGourtyDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Sarah P HudsonDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID 0000-0002-6718-2190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posttranslational modifications of proteins can impact their therapeutic efficacy, stability, and potential for pharmaceutical development. The Group A

Indexed as

Biological ProductsStreptococcus pyogenesAdhesins, BacterialEndopeptidasesHumansProtein Sorting SignalsAdhesins, BacterialBiological ProductsC5a peptidaseEndopeptidasesProtein Sorting SignalsbiopharmaceuticalC5a peptidasepropeptide cleavageprotein purificationprotein stability

Identifiers

PMID37406301
PMCPMC10410607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.