ArticleScience translational medicine2023
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease.
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Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
14.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- Neuroinflammatory fluid biomarkers in patients with Alzheimer's disease: a systematic literature review.Molecular psychiatry · 2025Pooled it
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- Semaglutide attenuates neuroinflammation in male mice.Nature communications · 2026Article
- Peroxiredoxin-Mediated Redox Regulation in Neurons: From Neurite Development to Degeneration.Antioxidants (Basel, Switzerland) · 2026Review
- Reproducibility-driven discovery and systematic benchmarking reveal a robust cerebrospinal fluid proteomic signature in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Aging-related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
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- Understanding Neurodegenerative Diseases From the -Omics Perspective: Lessons Learnt.Annals of neurology · 2026Review
- Clonal CD8Nature immunology · 2026Article
- The Impact of Structural Variation on Alzheimer's Disease in the Alzheimer's Disease Sequencing Project.Research square · 2026Article
- 15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN.NPJ dementia · 2026Article
- Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neurons.Molecular neurodegeneration advances · 2026Article
- SPP1 (osteopontin): a key regulator orchestrating cancer progression and non-cancerous pathologies - therapeutic opportunities and future directions.Frontiers in cell and developmental biology · 2026Review
- Approaches to deorphanize secretome: Classical, computational, and next generation strategies to reveal ligand-receptor networks.EXO : beyond the cell · 2026Article
- CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Development of Plasma Protein Classification Models for Alzheimer's Disease Using Multiple Machine Learning Approaches.International journal of molecular sciences · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 8 institutions in 2 countries.
Yun Ju SungDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-8021-4070
Chengran YangDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0003-4577-5590
Joanne NortonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
Matt JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
Anne FaganCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Randall J BatemanCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-7729-1702
Richard J PerrinCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-3443-7716
John C MorrisCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0001-9820-5618
Martin R FarlowDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7897-5471
Jasmeer P ChhatwalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7792-1698
Peter R SchofieldNeuroscience Research Australia, Randwick, NSW 2031, Australia.ORCID 0000-0003-2967-9662
Helena ChuiDepartment of Neurology, University of Southern California, Los Angeles, CA 90089, USA.
Fengxian WangDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-7677-5406
Brenna NovotnyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0003-4732-1736
Abdallah EteleebDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0001-9045-250X
Celeste KarchDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-6854-5547
Suzanne E SchindlerCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-1680-1465
Herve RhinnLeal Therapeutics, 17 Briden St., Office 329, Worcester, MA 01605, USA.
Erik C B JohnsonGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-0604-2944
Hamilton Se-Hwee OhDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.ORCID 0000-0001-8192-7593
Jarod Evert RutledgeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.ORCID 0000-0001-7790-2801
Eric B DammerGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0003-2947-7606
Nicholas T SeyfriedGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-8694-9211
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.ORCID 0000-0001-5893-0831
Oscar HarariDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-2635-6975
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-0276-2899
Washington University in St. Louis · USEmory University · USStanford University · USBiomedical Research Models (United States) · USHarvard University · USIndiana University School of MedicineUniversity of Southern California · USUNSW Sydney · AU
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MUSING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0MIdentifying Rare Variants that Increase Risk for Alzheimer's DiseaseRF1AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2019 to 2019
$3.6MGENETIC MODIFIERS OF CEREBROSPINAL FLUID TREM2 IN ALZHEIMER'S DISEASERF1AG058501 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, PICCIO, LAURA · 2018 to 2018
$3.5MThe Familial Alzheimer Sequencing (FASe) ProjectU01AG058922 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2018 to 2022
$3.5MSex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's DiseaseRF1AG074007 · NIA · WASHINGTON UNIVERSITY · PI SUNG, YUNJU · 2021 to 2021
$2.7MIDENTIFYING RARE VARIANTS THAT INCREASE RISK FOR ALZHEIMER'S DISEASER01AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2013 to 2017
$2.7MNIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG044546NIA NIH HHS RF1 AG044546NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS RF1 AG074007NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG058922NIA NIH HHS U19 AG032438
Abstract
Proteomic studies for Alzheimer's disease (AD) are instrumental in identifying AD pathways but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study analyzing 1305 proteins in brain tissue, cerebrospinal fluid (CSF), and plasma from patients with sporadic AD,
Indexed as
Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainHeterozygoteHumansImmunity, InnateProteomicstau ProteinsAmyloid beta-PeptidesBiomarkerstau Proteins
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