ReviewChemical reviews2023
Anti-Markovnikov Intermolecular Hydroamination of Alkenes and Alkynes: A Mechanistic View.
Review in Chemical reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Modular Access to α-Tertiary Amines: Electrochemical Tandem Di-Functionalization of Olefins With Ammonia Surrogates and Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Cobalt-Catalyzed Radical Ligand Transfer (RLT) Enables Remote-Markovnikov Hydroamination of Alkenes.Angewandte Chemie (International ed. in English) · 2026Article
- Amine/ammonium buffering enables efficient anti-Markovnikov hydroamination of olefins with alkylamines.Nature communications · 2026Article
- Article
- NiH-Catalyzed Enantioconvergent α-Alkenylation of Carbonyl Compounds via Markovnikov Alkyne Hydronickellation.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Advances in Catalysis Using N-Heterocyclic Carbene Platinum Complexes.Molecules (Basel, Switzerland) · 2026Review
- Direct Aziridine Synthesis from Amines and Styrene Derivatives via a Base-Promoted Oxidative Cascade Reaction.Journal of the American Chemical Society · 2026Article
- Recent advances in copper-catalyzed direct hydroamination of alkenes with (hetero)aromatic amines.Beilstein journal of organic chemistry · 2026Review
- Emergent Mechanisms in Biocatalysis.ACS central science · 2025Review
- Indirect Anti-Markovnikov Hydrofunctionalization of Terminal Alkenes via an Alkenyl Thianthrenium Intermediate.Angewandte Chemie (International ed. in English) · 2025Article
- Room-Temperature Intermolecular Hydroamination of Vinylarenes Catalyzed by Alkali-Metal Ferrate Complexes.ACS organic & inorganic Au · 2025Article
- MXenes as Heterogeneous Thermal Catalysts: Regioselective Anti-Markovnikov Hydroamination of Terminal Alkynes with 10Journal of the American Chemical Society · 2025Article
- Aminoalkylation of Alkenes Enabled by Triple Radical Sorting.Journal of the American Chemical Society · 2025Article
- Biomimetic Dehydrogenative Intermolecular Formal Allylic Amidation of Branched α-Olefins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols.Angewandte Chemie (International ed. in English) · 2024Article
- Rhodium-catalyzed atropodivergent hydroamination of alkynes by leveraging two potential enantiodetermining steps.Science advances · 2024Article
- Article
- Intermolecular Anti-Markovnikov Hydroamination of Alkenes with Sulfonamides, Sulfamides, and Sulfamates.ACS catalysis · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroamination, the addition of an N-H bond across a C-C multiple bond, is a reaction with a great synthetic potential. Important advances have been made in the last decades concerning catalysis of these reactions. However, controlling the regioselectivity in the amine addition toward the formation of anti-Markovnikov products (addition to the less substituted carbon) still remains a challenge, particularly in intermolecular hydroaminations of alkenes and alkynes. The goal of this review is to collect the systems in which intermolecular hydroamination of terminal alkynes and alkenes with anti-Markovnikov regioselectivity has been achieved. The focus will be placed on the mechanistic aspects of such reactions, to discern the step at which regioselectivity is decided and to unravel the factors that favor the anti-Markovnikov regioselectivity. In addition to the processes entailing direct addition of the amine to the C-C multiple bond, alternative pathways, involving several reactions to accomplish anti-Markovnikov regioselectivity (formal hydroamination processes), will also be discussed in this review. The catalysts gathered embrace most of the metal groups of the Periodic Table. Finally, a section discussing radical-mediated and metal-free approaches, as well as heterogeneous catalyzed processes, is also included.
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Registered trials
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