ArticlePloS one2023
Contributions of neighborhood social environment and air pollution exposure to Black-White disparities in epigenetic aging.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Assessing differences in epigenetic aging markers between sexual or gender minority and straight cisgender adults using the Coronary Artery Risk Development in Young Adults cohort.Social science & medicine (1982) · 2026Article
- Neighborhood Violence and Safety: Report from the MACS WIHS Combined Cohort Study.AIDS and behavior · 2026Article
- The contribution of social and economic factors to accelerated biological aging differences between non-Hispanic Black and White adults in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The use of race and ethnicity in air pollution epidemiology and methodological recommendations: A scoping review focusing on California.Environmental epidemiology (Philadelphia, Pa.) · 2026Review
- Research progress on the mechanisms of Panax ginseng and its active components in maintaining skin homeostasis and disease intervention.Chinese medicine · 2026Review
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Social determinants of vulnerability to nitrogen oxide- and sulfur dioxide-related bone damage among postmenopausal women in the United States.Frontiers in public health · 2026Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology.JAMA neurology · 2025Article
- Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States.Biopsychosocial science and medicine · 2025Article
- Cumulative neighborhood disadvantage and racial and geographic disparities in epigenetic aging.SSM - population health · 2025Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.medRxiv : the preprint server for health sciences · 2025Article
- The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Influence of race, ethnicity, and sex on the performance of epigenetic predictors of phenotypic traits.Clinical epigenetics · 2025Article
- Neighborhood-level deprivation and survival in lung cancer.BMC cancer · 2024Article
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Psychosocial Disadvantage During Childhood and Midlife Health: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Why location matters: associations between county-level characteristics and availability of National Cancer Oncology Research Program and National Cancer Institute sites.JNCI cancer spectrum · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Racial disparities in many aging-related health outcomes are persistent and pervasive among older Americans, reflecting accelerated biological aging for Black Americans compared to White, known as weathering. Environmental determinants that contribute to weathering are poorly understood. Having a higher biological age, measured by DNA methylation (DNAm), than chronological age is robustly associated with worse age-related outcomes and higher social adversity. We hypothesize that individual socioeconomic status (SES), neighborhood social environment, and air pollution exposures contribute to racial disparities in DNAm aging according to GrimAge and Dunedin Pace of Aging methylation (DPoAm). We perform retrospective cross-sectional analyses among 2,960 non-Hispanic participants (82% White, 18% Black) in the Health and Retirement Study whose 2016 DNAm age is linked to survey responses and geographic data. DNAm aging is defined as the residual after regressing DNAm age on chronological age. We observe Black individuals have significantly accelerated DNAm aging on average compared to White individuals according to GrimAge (239%) and DPoAm (238%). We implement multivariable linear regression models and threefold decomposition to identify exposures that contribute to this disparity. Exposure measures include individual-level SES, census-tract-level socioeconomic deprivation and air pollution (fine particulate matter, nitrogen dioxide, and ozone), and perceived neighborhood social and physical disorder. Race and gender are included as covariates. Regression and decomposition results show that individual-level SES is strongly associated with and accounts for a large portion of the disparity in both GrimAge and DPoAm aging. Higher neighborhood deprivation for Black participants significantly contributes to the disparity in GrimAge aging. Black participants are more vulnerable to fine particulate matter exposure for DPoAm, perhaps due to individual- and neighborhood-level SES, which may contribute to the disparity in DPoAm aging. DNAm aging may play a role in the environment "getting under the skin", contributing to age-related health disparities between older Black and White Americans.
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