Trial reporteLife2023
Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial.
Trial report in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06980090 (Neural Mechanisms of Interpersonal Expectations on Negative Affect), which is not on this map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neural Mechanisms of Interpersonal Expectations on Negative Affect
Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Effect of acupuncture treatment for patients with knee osteoarthritis on brain fluctuation amplitude and functional connectivity: a randomized three-armed fMRI study.BMC complementary medicine and therapies · 2025Trial
- Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study.Metabolomics : Official journal of the Metabolomic Society · 2023Trial
- Review
- Article
- Measuring and appraising placebo effects in clinical trials: contemporary challenges and approaches in psychiatry.The lancet. Psychiatry · 2026Review
- Structure-Guided Design of Cyclic Peptide: A Potent Inhibitor Targeting PD-1/PD-L1 Axis with Antitumor Activity.International journal of molecular sciences · 2025Article
- The Perceived Value of Pharmacogenetic Testing in Depression Treatment: Mixed-Methods Results From the PRIME Care Study.Psychiatric services (Washington, D.C.) · 2025Article
- Illness Expectations and Asthma Symptoms: A 6-Month Longitudinal Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- "Ready-to-use" two-week home exercise program targeting depressive symptoms: pilot study.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tailoring interventions to patient subgroups can improve intervention outcomes for various conditions. However, it is unclear how much of this improvement is due to the pharmacological personalisation versus the non-specific effects of the contextual factors involved in the tailoring process, such as the therapeutic interaction. Here, we tested whether presenting a (placebo) analgesia machine as personalised would improve its effectiveness. Methods: We recruited 102 adults in two samples ( Results: Participants told that the machine was personalised reported more relief in pain intensity than the control group in both the feasibility study (standardised Conclusions: We present some of the first evidence that framing a sham treatment as personalised increases its effectiveness. Our findings could potentially improve the methodology of precision medicine research and inform practice. Funding: This study was funded by the Social Science and Humanities Research Council (93188) and Genome Québec (95747).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.