ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2023
Treatment burden and health-related quality of life of patients with multimorbidity: a cross-sectional study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Quality of life in primary aldosteronism, medical vs surgical treatment: a systematic review and meta-analysis.Journal of endocrinological investigation · 2026Pooled it
- Pooled it
- The life quality of people living with chronic disease in Africa: a systematic narrative synthesis.The Pan African medical journal · 2024Pooled it
- Evaluating health-related quality of life in Ethiopia: systematic review and meta-analysis of EQ-5D-based studies.Frontiers in epidemiology · 2024Pooled it
- Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study.Drugs & aging · 2025Trial
- Self-Rated Health Associated with Chronic Diseases and Types of Physical Activity Among Middle-Aged and Older Adults: A Cross-Sectional Study Using Explainable Machine Learning.Journal of clinical medicine · 2026Article
- Factors Associated with Treatment Burden in Older Adults with Multimorbidity and Implications for Potential Reduction Strategies: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Self-Care Experiences and Support Needs of Community-Dwelling Older Adults With Multimorbidity: A Qualitative Study Informed by the Caring Life-Course Theory.Journal of clinical nursing · 2026Article
- Article
- Understanding Remission of Long-Term Conditions Through Electronic Health Records: Scoping Review.Journal of medical Internet research · 2026Article
- Medication process-related burden among informal caregivers of people with dementia: a nationwide cross-sectional survey in Germany.BMC health services research · 2026Article
- The Treatment Burden for Multimorbidity Scale: A Development and Psychometric Validation Study.Nursing & health sciences · 2026Article
- The association between disease status and health-related quality of life: evidence from a cross-sectional survey across mainland China.Health and quality of life outcomes · 2026Article
- Physician Characteristics Associated with Prioritizing Treatment Burden in Outpatient Care for Older Adults with Multimorbidity.JMA journal · 2026Article
- Analysing the impact of complex multimorbidity on health-related quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Experiences of medication burden among patients with multimorbidity in rural China: a qualitative study.Frontiers in medicine · 2026Article
- Unraveling the pathway from treatment burden to holistic health status in older adults with complex multimorbidity: the mediating roles of stress adaptation and depressive symptoms.Frontiers in public health · 2026Article
- Treatment Burden Among Older Adults in the United States, 2022.Journal of the American Geriatrics Society · 2025Article
- Article
- Perceived treatment burden and health-related quality of life in association with healthcare utilisation among patients attending multiple outpatient clinics.Health and quality of life outcomes · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
purposeThe aim of this study was to investigate treatment burden and its relationship with health-related quality of life (HRQoL) among patients with multimorbidity (two or more chronic diseases) who were taking prescription medications and attending the outpatient department of the University of Gondar Comprehensive Specialized Teaching Hospital.
methodsA cross-sectional study was conducted between March 2019 and July 2019. Treatment burden was measured using the Multimorbidity Treatment Burden Questionnaire (MTBQ), while HRQoL was captured using the Euroqol-5-dimensions-5-Levels (EQ-5D-5L).
resultsA total of 423 patients participated in the study. The mean global MTBQ, EQ-5D index, and EQ-VAS scores were 39.35 (± 22.16), 0.83 (± 0.20), and 67.32 (± 18.51), respectively. Significant differences were observed in the mean EQ-5D-Index (F [2, 81.88] 33.1) and EQ-VAS (visual analogue scale) scores (F [2, 75.48] = 72.87) among the treatment burden groups. Follow up post-hoc analyses demonstrated significant mean differences in EQ-VAS scores across the treatment burden groups and in EQ-5D index between the no/low treatment burden and high treatment burden, as well as between the medium treatment burden and high treatment burden. In the multivariate linear regression model, every one SD increase in the global MTBQ score (i.e., 22.16) was associated with a decline of 0.08 in the EQ-5D index (β - 0.38, 95%CI - 0.48, - 0.28), as well as a reduction of 9.4 in the EQ-VAS score (β - 0.51, 95%CI -0.60, - 0.42).
conclusionTreatment burden was inversely associated with HRQoL. Health care providers should be conscious in balancing treatment exposure with patients' HRQoL.
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