Evidence map›Paper›PMID 37405609›Full record

ArticleThe international journal of cardiovascular imaging2023

Comprehensive echocardiographic assessment of right ventricular function, pulmonary arterial elastic properties and ventricular-vascular coupling in adult patients with repaired tetralogy of fallot: clinical significance of 3D derived indices.

Antonio Vitarelli, Fabio Miraldi, Lidia Capotosto, Nicola Galea, Marco Francone, Livia Marchitelli, Nicola Viceconte, Costantino Smaldone, Enrico Mangieri, Bich Lien Nguyen and 3 more

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Article in The international journal of cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Antonio VitarelliDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy. vitar@tiscali.it.
Fabio MiraldiDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Lidia CapotostoDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Nicola GaleaDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Marco FranconeDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Livia MarchitelliDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Nicola ViceconteDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Costantino SmaldoneSan Carlo Hospital, Potenza, Italy.
Enrico MangieriDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Bich Lien NguyenDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Gaetano TanzilliDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Massimo ManconeDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Sulaiman Al-KindyDepts of Cardiology, Cardiac Surgery and Radiology, Sapienza University, Rome, Italy.
Sapienza University of Rome · ITCytodiagnostics (Canada) · CAOspedale San Carlo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to comprehensively analyze by three-dimensional speckle-tracking echocardiography (3DSTE) and Doppler echocardiography right ventricular (RV) performance, pulmonary arterial (PA) elastic properties and right ventricular-pulmonary artery coupling (RVPAC) in patients with repaired tetralogy of Fallot (rTOF) and assess the feasibility and clinical utility of related echocardiographic indices. Twenty-four adult patients with rTOF and twenty-four controls were studied. RV end-diastolic volume(3D-RVEDV), RV end-systolic volume(3D-RVESV), RV ejection fraction(3D-RVEF), RV longitudinal strain(3D-RVLS) and RV area strain(3D-RVAS) were calculated by 3DSTE. RV end-systolic area (RVESA) was obtained by planimetry. Pulmonary regurgitation (PR) was assessed as trivial/mild or significant by cardiac magnetic resonance (CMR) and color-Doppler. Pulmonary artery (PA) elastic properties were determined using two-dimensional/Doppler echocardiography. RV systolic pressure (RVSP) was measured using standard Doppler methods. RVPAC was assessed using various 3DSTE-derived parameters (3DRVAS/RVSP, 3DRVLS/RVESA, 3DRVAS/RVESV). Overall, 3DRVEF and 3DRVAS were impaired in rTOF patients compared with controls. PA pulsatility and capacitance were reduced (p = 0.003) and PA elastance was higher (p = 0.0007) compared to controls. PA elastance had a positive correlation with 3DRVEDV (r = 0.64, p = 0.002) and 3DRVAS (r = 0.51, p = 0.02). By ROC (receiver operating characteristics) analysis, 3DRVAS/RVESV, 3DRVAS/RVSP and 3DRVLS/RVESA cutoff values of 0.31%/mmHg, 0.57%/mmHg and 0.86%/mmHg, respectively, had 91%, 88% and 88% sensitivity and 81%, 81% and 79% specificity in identifying exercise capacity impairment. In rTOF patients increased 3DSTE-derived RV volumes and impaired RV ejection fraction and strain are associated with reduced PA pulsatility and capacitance and increased PA elastance. 3DSTE-derived RVPAC parameters using different afterload-markers are accurate indices of exercise capacity.

Indexed as

Hypertension, PulmonaryTetralogy of FallotVentricular Dysfunction, RightAdultClinical RelevanceEchocardiographyHumansPredictive Value of TestsPulmonary ArteryVentricular Function, RightPulmonary artery elastanceRepaired tetralogy of FallotRight ventricular functionRight ventricular-pulmonary artery couplingThree-dimensional speckle tracking echocardiography

Identifiers

PMID37405609
OpenAlexW4383187226

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.