ArticleFrontiers in nutrition2023
Deep eutectic solvent-ultrasound assisted extraction as a green approach for enhanced extraction of naringenin from
Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Ultrasonic-Assisted Extraction of Astaxanthin Using Hydrophobic Deep Eutectic Solvent: Process Optimization and Anti-Aging Activity Evaluation.Foods (Basel, Switzerland) · 2026Article
- Deep Eutectic Solvents for Sustainable Extraction of Bioactive Compounds from Biomass: Mechanistic Insights and Scale-Up Challenges.Molecules (Basel, Switzerland) · 2026Review
- Direct vs indirect ultrasound-assisted extraction of phenolics from wild sumac (Rhus tripartita): Optimization by Response Surface Methodology (RSM) and LC-MS profiling.Ultrasonics sonochemistry · 2026Article
- A Review of Classical and Rising Approaches the Extraction and Utilization of Marine Collagen.Biotech (Basel (Switzerland)) · 2025Review
- Comparison, optimization and antioxidant activity of ultrasound-assisted natural deep eutectic solvents extraction and traditional method: A greener route for extraction of flavonoid from Moringa oleifera Lam. leaves.Ultrasonics sonochemistry · 2024Article
- Optimization of an ultrasound-assisted extraction method to obtain gallic acid-rich extracts from mango seed kernels.Food science & nutrition · 2024Article
- NaDES Application in Cosmetic and Pharmaceutical Fields: An Overview.Gels (Basel, Switzerland) · 2024Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
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Abstract
Background: Naringenin (NA) is a natural flavonoid used in the formulation of a wide range of pharmaceutical, fragrance, and cosmetic products. In this research, NA was extracted from Methods: Six natural deep eutectic solvent systems were tested. Choline chloride was used as the hydrogen bond acceptor (HBA), and formic acid, ethylene glycol, lactic acid, urea, glycerol, and citric acid were used as hydrogen bond donors (HBD). Results: Based on the results of single-factor experiments, response surface methodology using a Box-Behnken design was applied to determine the optimal conditions for UAE-DES. According to the results, the optimal NA extraction parameters were as follows: DES-1 consisted of choline chloride (HBA) and formic acid (HBD) in a mole ratio of 2:1, an extraction time of 10 min, an extraction temperature of 50°C, an ultrasonic amplitude of 75 W, and a solid-liquid ratio of 1/60 g/mL. Extracted NA was shown to inhibit the activity of different enzymes Conclusion: Thus, the UAE-DES technique produced high-efficiency NA extraction while retaining bioactivity, implying broad application potential, and making it worthy of consideration as a high-throughput green extraction method.
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