ArticleRadiology. Cardiothoracic imaging2023
Prognostic Value of Different Thresholds for Myocardial Scar Quantification on Cardiac MRI Late Gadolinium Enhancement Images in Patients Receiving Implantable Cardioverter Defibrillators.
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Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Enhancing risk prediction for sudden cardiac death: quantitative late gadolinium enhancement analysis in hypertrophic cardiomyopathy.Insights into imaging · 2026Article
- Myocardial fibrosis predicts sudden cardiac death in patients with hypertrophic cardiomyopathy after cardiac electronic device implantation: Insights from cardiovascular magnetic resonance imaging.Heart rhythm O2 · 2026Article
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14 authors at 1 institution in 3 countries.
Tamar ShalmonFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).
Faisal Mhd Dib HamadFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0003-4799-2089
Laura Jimenez-JuanFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0003-0560-7445
Anish KirpalaniFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).
Camila M Urzua FresnoFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0001-5145-4430
Luciano FoladorFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0002-9828-8107
Nigel S TanFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0001-6717-4716
Sheldon M SinghFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0002-8210-3112
Yin GeFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0003-3145-3427
Paul DorianFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).
João A C LimaFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0001-8756-6995
Kathy C K WongFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).
Djeven P DevaFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).
Andrew T YanFrom the Department of Medical Imaging (T.S., F.M.D.H., L.J.J., A.K., C.M.U.F., L.F., D.P.D., A.T.Y.), Li Ka Shing Knowledge Institute (A.K., P.D., D.P.D., A.T.Y.), and Division of Cardiology (N.S.T., Y.G., P.D., A.T.Y.), Unity Health Toronto, University of Toronto, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8; Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (S.M.S.); Division of Cardiology and The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.); and Department of Radiology, The University of Hong Kong, Hong Kong (K.C.K.W.).ORCID 0000-0002-2063-7485
Johns Hopkins University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To compare the predictive value of different myocardial scar quantification thresholds using cardiac MRI for appropriate implantable cardioverter defibrillator (ICD) shock and mortality. Materials and Methods: In this retrospective, two-center observational cohort study, patients with ischemic or nonischemic cardiomyopathy underwent cardiac MRI prior to ICD implantation. Late gadolinium enhancement (LGE) was first determined visually and then quantified by blinded cardiac MRI readers using different SDs above the mean signal of normal myocardium, full-width half-maximum, and manual thresholding. The intermediate signal "gray zone" was calculated as the differences between different SDs. Results: Among 374 consecutive eligible patients (mean age, 61 years ± 13 [SD]; mean left ventricular ejection fraction, 32% ± 14; secondary prevention, 62.7%), those with LGE had a higher rate of appropriate ICD shock or death than those without (37.5% vs 26.6%, log-rank Conclusion: Presence of LGE was associated with a higher rate of appropriate ICD shock or death. Although none of the scar quantification techniques predicted outcomes, the gray zone both in infarct and nonischemic scar was an independent predictor and may refine risk stratification.
Indexed as
Implantable Cardioverter DefibrillatorMRIScar QuantificationSudden Cardiac Death
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