Evidence map›Paper›PMID 37404789›Full record

ArticleRadiology. Cardiothoracic imaging2023

Detection of Early Diffuse Myocardial Fibrosis and Inflammation in Chagas Cardiomyopathy with T1 Mapping and Extracellular Volume.

Rodrigo J L Melo, Antonildes N Assunção, Thamara C Morais, Cesar H Nomura, Mauricio I Scanavacca, Martino Martinelli-Filho, Felix J A Ramires, Fabio Fernandes, Barbara M Ianni, Charles Mady and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rodrigo J L MeloFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.ORCID https://orcid.org/0000-0002-2884-1712
Antonildes N AssunçãoFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.ORCID https://orcid.org/0000-0002-2567-017X
Thamara C MoraisFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Cesar H NomuraFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.ORCID https://orcid.org/0000-0002-7131-6614
Mauricio I ScanavaccaFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Martino Martinelli-FilhoFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Felix J A RamiresFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Fabio FernandesFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Barbara M IanniFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Charles MadyFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.
Carlos E RochitteFrom the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar 44, Andar AB, Cerqueira Cesar, São Paulo 05403-000 SP, Brazil.ORCID https://orcid.org/0000-0003-4505-3344
Cardiovascular Research Center · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate myocardial T1 mapping and extracellular volume (ECV) parameters in different stages of Chagas cardiomyopathy and determine whether they are predictive of disease severity and prognosis. Materials and Methods: Prospectively enrolled participants (July 2013 to September 2016) underwent cine and late gadolinium enhancement (LGE) cardiac MRI and T1 mapping with a precontrast (native) or postcontrast modified Look-Locker sequence. The native T1 and ECV values were measured among subgroups that were based on disease severity (indeterminate, Chagas cardiomyopathy with preserved ejection fraction [CCpEF], Chagas cardiomyopathy with midrange ejection fraction [CCmrEF], and Chagas cardiomyopathy with reduced ejection fraction [CCrEF]). Cox proportional hazards regression and the Akaike information criterion were used to determine predictors of major cardiovascular events (cardioverter defibrillator implant, heart transplant, or death). Results: In 107 participants (90 participants with Chagas disease [mean age ± SD, 55 years ± 11; 49 men] and 17 age- and sex-matched control participants), the left ventricular (LV) ejection fraction and the extent of focal and diffuse or interstitial fibrosis were correlated with disease severity. Participants with CCmrEF and participants with CCrEF showed significantly higher global native T1 and ECV values than participants in the indeterminate, CCpEF, and control groups (T1: 1072 msec ± 34 and 1073 msec ± 63 vs 1010 msec ± 41, 1005 msec ± 69, and 999 msec ± 46; ECV: 35.5% ± 3.6 and 35.0% ± 5.4 vs 25.3% ± 3.5, 28.2% ± 4.9, and 25.2% ± 2.2; both Conclusion: Myocardial native T1 and ECV values were correlated with Chagas disease severity and may serve as markers of myocardial involvement in Chagas cardiomyopathy that precede LGE and LV dysfunction.

Indexed as

CardiacChagas CardiomyopathyHeartImaging SequencesMRI

Identifiers

PMID37404789
PMCPMC10316290
OpenAlexW4380792771

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.