Evidence map›Paper›PMID 37404782›Full record

ArticleRadiology. Cardiothoracic imaging2023

Detection of Myocardial Ischemia Using Cardiovascular MRI Stress T1 Mapping: A Miniature-Swine Validation Study.

Baiyan Zhuang, Chen Cui, Jian He, Jing Xu, Gang Yin, Xuejing Duan, Guangxin Yue, Hongyue Wang, Xin Wang, Arlene Sirajuddin and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Baiyan ZhuangFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).ORCID https://orcid.org/0000-0003-3873-4950
Chen CuiFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).ORCID 0000-0002-8996-6623
Jian HeFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).ORCID 0000-0001-6899-5145
Jing XuFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
Gang YinFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
Xuejing DuanFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
Guangxin YueFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
Hongyue WangFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
Xin WangFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
Arlene SirajuddinFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).ORCID 0000-0001-9183-5983
Shihua ZhaoFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).ORCID 0000-0002-7798-0364
Minjie LuFrom the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).ORCID https://orcid.org/0000-0001-8696-318X
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To assess the efficacy of cardiac MRI stress T1 mapping in detecting ischemic and infarcted myocardium in a miniature-swine model, using pathologic findings as the reference standard. Materials and Methods: Ten adult male Chinese miniature swine, with coronary artery stenosis induced by an ameroid constrictor, and two healthy control swine were studied. Cardiac 3-T MRI rest and adenosine triphosphate stress T1 mapping and perfusion images, along with resting and late gadolinium enhancement images, were acquired at baseline and weekly up to 4 weeks after surgery or until humanely killed. A receiver operating characteristic analysis was used to analyze the performance of T1 mapping in the detection of myocardial ischemia. Results: In the experimental group, both the infarcted myocardium (ΔT1 = 10 msec ± 2 [SD]; ΔT1 percentage = 0.7% ± 0.1) and ischemic myocardium (ΔT1 = 10 msec ± 2; ΔT1 percentage = 0.9% ± 0.2) exhibited reduced T1 reactivity compared with the remote myocardium (ΔT1 = 53 msec ± 7; ΔT1 percentage = 4.7% ± 0.6) and normal myocardium (ΔT1 = 56 msec ± 11; ΔT1 percentage = 4.9% ± 1.1). Receiver operating characteristic analysis demonstrated high diagnostic performance of ΔT1 in detecting ischemic myocardium, with an area under the curve (AUC) of 0.84 ( Conclusion: Using histopathologic validation in a swine model, noninvasive cardiac MRI stress T1 mapping demonstrated high performance in detecting ischemic and infarcted myocardium without the need for contrast agents.

Indexed as

Coronary Artery DiseaseMRIMyocardial IschemiaRest T1 MappingStress T1 MappingSwine Model

Identifiers

PMID37404782
PMCPMC10316297
OpenAlexW4381614434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.