ArticleJournal of dental sciences2023
Accumulated X-ray irradiation induces miR-187-5p upregulation mediating fibrotic buccal mucosal fibroblasts activities via DKK2.
Article in Journal of dental sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background/purpose: With the wide application of X-rays in dental examinations, it is necessary to assess its potential risk and explore an effective indicator. This study aimed to analyze the response of miR-187-5p to X-ray irradiation and to evaluate its potential of predicting X-ray potential dangers. Materials and methods: Patients that had to receive dental X-ray examination were enrolled and the expression of miR-187-5p in the buccal mucosa swabs were detected by real-time quantitative polymerase chain reaction (PCR). The effect of miR-187-5p on fibrotic buccal mucosal fibroblasts (fBMFs) activities was assessed by cell migration and invasion and the expression of fibrosis markers. In mechanism, the interaction between miR-187-5p and DKK2 and their co-regulatory effects were also estimated. Results: Significant upregulation of miR-187-5p was observed in the patients who received over twice X-ray irradiation. miR-187-5p was found to regulate the luciferase and expression level of DKK2 in fBMFs. Moreover, miR-187-5p knockdown dramatically suppressed the migration and invasion of fBMFs and inhibited the expression of α-SMA, collagen I, and collagen II, three typical fibrosis markers. Silencing could reverse the inhibitory effect of miR-187-5p knockdown on fBMFs activities. Conclusion: Accumulated X-ray irradiation could induce miR-187-5p upregulation, which could regulate the fBMFs activities via modulating DKK2. miR-187-5p could serve as an indicator of X-ray examination dangers to prevent the potential risk during the accumulated application of X-ray irradiation in the dental examination.
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