Evidence map›Paper›PMID 37404244›Full record

ArticleJournal of the Endocrine Society2023

Interplay of Cortisol, Testosterone, and Abdominal Fat Mass in Normal-weight Women With Polycystic Ovary Syndrome.

Daniel A Dumesic, Adina F Turcu, Haiping Liu, Tristan R Grogan, David H Abbott, Gwyneth Lu, Devyani Dharanipragada, Gregorio D Chazenbalk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel A DumesicDepartment of Obstetrics and Gynecology, University of California, Los Angeles, 1Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0003-0387-1277
Adina F TurcuDivision of Metabolism, Endocrinology, Nutrition and Diabetes, University of Michigan, Ann Arbor, MI 48103, USA.ORCID https://orcid.org/0000-0001-9831-6190
Haiping LiuDivision of Metabolism, Endocrinology, Nutrition and Diabetes, University of Michigan, Ann Arbor, MI 48103, USA.
Tristan R GroganDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, CA 90024, USA.ORCID https://orcid.org/0000-0001-9471-2938
David H AbbottDepartment of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of WI-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0002-8249-263X
Gwyneth LuDepartment of Obstetrics and Gynecology, University of California, Los Angeles, 1Los Angeles, CA 90095, USA.
Devyani DharanipragadaDepartment of Obstetrics and Gynecology, University of California, Los Angeles, 1Los Angeles, CA 90095, USA.
Gregorio D ChazenbalkDepartment of Obstetrics and Gynecology, University of California, Los Angeles, 1Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0003-2065-3343
University of California, Los Angeles · USUniversity of Michigan · USUniversity of Wisconsin–Madison · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENP50HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SLAYDEN, OV D · 2014 to 2021
$14.7M
NCATS NIH HHS UL1 TR001881NICHD NIH HHS P50 HD071836NIH HHS P51 OD011092
6 · The paper itself

Abstract

Context: Ovarian and adrenal steroidogenesis underlie endocrine-metabolic dysfunction in polycystic ovary syndrome (PCOS). Adipocytes express aldo-keto reductase 1C3 and type 1 11β-hydroxysteroid dehydrogenase, which modulate peripheral androgen and cortisol production. Objectives: To compare serum adrenal steroids, including 11-oxygenated androgens (11-oxyandrogens), cortisol, and cortisone between normal-weight women with PCOS and body mass index- and age-matched ovulatory women with normal-androgenic profiles (controls), and assess whether adrenal steroids associate with abdominal adipose deposition. Design: Prospective, cross-sectional, cohort study. Setting: Academic medical center. Patients: Twenty normal-weight women with PCOS and 20 body mass index-/age-matched controls. Interventions: Blood sampling, IV glucose tolerance testing, and total-body dual-energy x-ray absorptiometry. Main Outcome Measures: Clinical characteristics, hormonal concentrations, and body fat distribution. Results: Women with PCOS had higher serum total/free testosterone (T) and androstenedione (A4) levels and a greater android/gynoid fat mass than controls (androgens Conclusion: Reduced cortisol may protect against preferential abdominal fat mass in normal-weight PCOS women with normal serum 11-oxyandrogens.

Indexed as

adipocyteadiposeAKR1C3androgensandrostenedionepolycystic ovary syndrometestosterone

Identifiers

PMID37404244
PMCPMC10315644
OpenAlexW4379743315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.