Evidence map›Paper›PMID 37403881›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2023

Interferon-gamma gene diplotype (AA-rs2069716 / AG-rs2069727) may play an important role during secondary outcomes of severe dengue in Brazilian patients.

Cristiane Campello Bresani-Salvi, Clarice Neuenschwander Lins de Morais, Heytor Victor Pereira da Costa Neco, Pablo Cantalice Santos Farias, André Filipe Pastor, Raul Emídio de Lima, Ulisses Ramos Montarroyos, Bartolomeu Acioli-Santos

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Cristiane Campello Bresani-SalviFundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-1295-0885
Clarice Neuenschwander Lins de MoraisFundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-0887-8163
Heytor Victor Pereira da Costa NecoFundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-2393-1612
Pablo Cantalice Santos FariasUniversidade Federal de Pernambuco, Departamento de Genética, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0001-8734-3468
André Filipe PastorInstituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano, Pernambuco, Floresta, Brazil.ORCID http://orcid.org/0000-0002-5133-9616
Raul Emídio de LimaFundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0003-4933-1241
Ulisses Ramos MontarroyosUniversidade de Pernambuco, Instituto de Ciências Biológicas, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0001-8967-5693
Bartolomeu Acioli-SantosFundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia, Recife, Pernambuco, Brazil.ORCID http://orcid.org/0000-0002-4994-0648
Fundação Oswaldo Cruz · BRInstituto Federal do Sertão Pernambucano · BRUniversidade de Pernambuco · BRUniversidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is a global and growing health threat, especially in Southeast Asia, West Pacific and South America. Infection by the dengue virus (DENV) results in dengue fever, which can evolve to severe forms. Cytokines, especially interferons, are involved in the immunopathogenesis of dengue fever, and so may influence the disease outcomes. The aim of this study was to investigate the association between severe forms of dengue and two single nucleotide polymorphisms (SNPs) in the interferon-gamma gene (IFNG): A256G (rs2069716) and A325G (rs2069727). We included 274 patients infected with DENV serotype 3: 119 cases of dengue without warning signs (DWoWS), and 155 with warning signs (DWWS) or severe dengue (SD). DNA was extracted, and genotyped with Illumina Genotyping Kit or real time PCR (TaqMan probes). We estimated the adjusted Odds Ratios (OR) by multivariate logistic regression models. When comparing with the ancestral AA/AA diplotype (A256G/A325G), we found a protective association of the AA/AG against DWWS/SD among patients with secondary dengue (OR 0.51; 95% IC 0.24-1.10, p = 0.085), adjusting for age and sex. The variant genotype at locus A325G of the IFNG, in combination with the ancestral genotype at locus A256G, can protect against severe clinical forms of secondary dengue in Brazilian DENV3-infected patients.

Indexed as

Interferon-gammaSevere DengueBrazilDengue VirusGenotypeHumansPolymorphism, Single NucleotideIFNG protein, humanInterferon-gamma

Identifiers

PMID37403881
PMCPMC10313327
OpenAlexW4382786795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.