Evidence map›Paper›PMID 37403712›Full record

ArticleAnnals of clinical and translational neurology2023

Subacute aphasia recovery is associated with resting-state connectivity within and beyond the language network.

Melissa D Stockbridge, Andreia V Faria, Julius Fridriksson, Chris Rorden, Leonardo Bonilha, Argye E Hillis

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In one paragraph

Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melissa D StockbridgeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.ORCID 0000-0001-9069-1236
Andreia V FariaDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.
Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, 29208, South Carolina, USA.
Chris RordenDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, 29208, South Carolina, USA.
Leonardo BonilhaDepartment of Neurology, Emory University School of Medicine, Atlanta, 30322, Georgia, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BONILHA, LEONARDO F · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Trans-cranial Direct Current Stimulation to Treat Aphasia: Phase II TrialU01DC011739 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2012 to 2016
$4.4M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS U01 DC011739NIH HHS S10 OD021648
6 · The paper itself

Abstract

objectiveTo examine changes to connectivity after aphasia treatment in the first 3 months after stroke.

methodsTwenty people experiencing aphasia within the first 3 months of stroke completed MRI before and immediately following 15 hours of language treatment. They were classified based on their response to treatment on a naming test of nouns as either high responders (10% improvement or more), or low responders (<10% improvement). Groups were similar in age, gender distribution, education, days since stroke, stroke volume, and baseline severity. Resting-state functional connectivity analysis was limited to the connectivity of the left fusiform gyrus with the bilateral inferior frontal gyrus, supramarginal gyrus, angular gyrus, and superior, middle, and inferior temporal gyrus, based on previous studies showing the importance of left fusiform gyrus in naming performance.

resultsBaseline ipsilateral connectivity between the left fusiform gyrus and the language network was similar between high and low responders to therapy when controlling for stroke volume. Following therapy, change in connectivity was significantly greater among high responders between the left fusiform gyrus and the ipsilateral and contralateral pars triangularis, ipsilateral pars opercularis and superior temporal gyrus, and contralateral angular gyrus when compared with low responders.

interpretationAn account of these findings incorporates primarily proximal connectivity restoration, but also potentially reflects select contralateral compensatory reorganization. The latter is often associated with chronic recovery, reflecting the transitional nature of the subacute period.

Indexed as

AphasiaStrokeBrainHumansLanguageMagnetic Resonance Imaging

Identifiers

PMID37403712
PMCPMC10502663

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.