Evidence map›Paper›PMID 37403570›Full record

ArticleMedical physics2023

Comprehensive evaluation and new recommendations in the use of Gafchromic EBT3 film.

Kevin Liu, Patrik Gonçalves Jorge, Ramesh Tailor, Raphaël Moeckli, Emil Schüler

Abstract read
In one paragraph

Article in Medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Volumetric FLASH dosimetryPhysics in medicine and biology · 2026
    Article
  3. Article
  4. Development and application ofPhysics and imaging in radiation oncology · 2026
    Article
  5. Article
  6. Article
  7. Investigating the oxygen dependence of FLASH-RT using electron paramagnetic resonance imaging.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
    Article
  8. On temporal evolution of the response of EBT4 radiochromic films.Journal of applied clinical medical physics · 2026
    Article
  9. A review on radiochromic film dosimetry in radiation therapy.Journal of applied clinical medical physics · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kevin LiuDivision of Radiation Oncology, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Patrik Gonçalves JorgeInstitute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Ramesh TailorDivision of Radiation Oncology, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Raphaël MoeckliInstitute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Emil SchülerDivision of Radiation Oncology, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Research Supplements to Promote Diversity in Health-Related Research: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevanceR01CA266673 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHUELER, EMIL · 2022 to 2025
$3.5M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA266673
6 · The paper itself

Abstract

backgroundGafchromic film's unique properties of tissue-equivalence, dose-rate independence, and high spatial resolution make it an attractive choice for many dosimetric applications. However, complicated calibration processes and film handling limits its routine use. PURPOSE: We evaluated the performance of Gafchromic EBT3 film after irradiation under a variety of measurement conditions to identify aspects of film handling and analysis for simplified but robust film dosimetry.

methodsThe short- (from 5 min to 100 h) and long-term (months) film response was evaluated for clinically relevant doses of up to 50 Gy for accuracy in dose determination and relative dose distributions. The dependence of film response on film-read delay, film batch, scanner type, and beam energy was determined.

resultsScanning the film within a 4-h window and using a standard 24-h calibration curve introduced a maximum error of 2% over a dose range of 1-40 Gy, with lower doses showing higher uncertainty in dose determination. Relative dose measurements demonstrated <1 mm difference in electron beam parameters such as depth of 50% of the maximum dose value (R

conclusionsThis is the first comprehensive evaluation of the temporal and batch dependence of Gafchromic EBT3 film evaluated on consolidated data over 8 years. The relative dosimetric measurements were insensitive to the type of calibration applied (batch- or time-specific) and in-depth time-dependent dosimetric signal behaviors can be established for film scanned outside of the recommended 16-24 h post-irradiation window. We generated guidelines based on our findings to simplify film handling and analysis and provide tabulated dose- and time-dependent correction factors to achieve this without reducing the accuracy of dose determination.

Indexed as

Film DosimetryCalibrationUncertaintyEBT3film dosimetryradiochromic filmtemporal dependence

Identifiers

PMID37403570
PMCPMC10766858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.