Evidence map›Paper›PMID 37403487›Full record

ArticleJournal of the Royal Society, Interface2023

Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers.

Yimin Luo, Mengyang Gu, Minwook Park, Xinyi Fang, Younghoon Kwon, Juan Manuel Urueña, Javier Read de Alaniz, Matthew E Helgeson, Cristina M Marchetti, Megan T Valentine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Vector nematodynamics with symmetry-driven energy exchange.The European physical journal. E, Soft matter · 2026
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yimin LuoDepartment of Mechanical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Mengyang GuDepartment of Statistics and Applied Probability, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Minwook ParkDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Xinyi FangDepartment of Statistics and Applied Probability, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Younghoon KwonDepartment of Mechanical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Juan Manuel UrueñaBioPACIFIC MIP, California NanoSystems Institute, Santa Barbara, CA 93106, USA.
Javier Read de AlanizDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Matthew E HelgesonDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Cristina M MarchettiDepartment of Physics, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Megan T ValentineDepartment of Mechanical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0003-4781-8478
University of California, Santa Barbara · USCalifornia NanoSystems Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of cells to reorganize in response to external stimuli is important in areas ranging from morphogenesis to tissue engineering. While nematic order is common in biological tissues, it typically only extends to small regions of cells interacting via steric repulsion. On isotropic substrates, elongated cells can co-align due to steric effects, forming ordered but randomly oriented finite-size domains. However, we have discovered that flat substrates with nematic order can induce global nematic alignment of dense, spindle-like cells, thereby influencing cell organization and collective motion and driving alignment on the scale of the entire tissue. Remarkably, single cells are not sensitive to the substrate's anisotropy. Rather, the emergence of global nematic order is a collective phenomenon that requires both steric effects and molecular-scale anisotropy of the substrate. To quantify the rich set of behaviours afforded by this system, we analyse velocity, positional and orientational correlations for several thousand cells over days. The establishment of global order is facilitated by enhanced cell division along the substrate's nematic axis, and associated extensile stresses that restructure the cells' actomyosin networks. Our work provides a new understanding of the dynamics of cellular remodelling and organization among weakly interacting cells.

Indexed as

Mass BehaviorAnisotropyCell Divisionactive nematicsanisotropycell migration

Identifiers

PMID37403487
PMCPMC10320338
OpenAlexW4383187008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.