ReviewCurrent neuropharmacology2024
Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.
Review in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Stress and alcohol impact network states involved in emotional processing: relevance of comorbid AUD and psychiatric illnesses.Psychopharmacology · 2026Pooled it
- C-low threshold mechanoreceptors: a novel target for health-tech in an increasingly touch-deprived world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Sex-related neuropsychiatric recovery from maternal perinatal depression and expression of monoamine and amino acid neurotransmitter levels in specific brain regions of adult offspring.Scientific reports · 2026Article
- Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.Psychological medicine · 2026Article
- Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk.BMC medicine · 2026Article
- The association of adverse childhood experiences with the progression of chronic kidney disease in children: a CKiD pilot study.Pediatric nephrology (Berlin, Germany) · 2026Article
- From use to abuse: psychological, neurobiological, and spiritual pathways in relational harm and recovery.Frontiers in behavioral neuroscience · 2026Article
- Perceived stress mediates the association between orbitofrontal cortex grey matter volume and depressive symptoms in older women.Scientific reports · 2025Article
- The effect of tropical cyclone on cognitive function in older adults: a longitudinal study from Thailand.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury.Biology · 2025Review
- Long-term GABA supplementation mitigates anxiety by modulating complement and neuroinflammatory pathways.NPJ science of food · 2025Article
- Flooding and Cognitive Health among Middle-Aged and Older Adults in Thailand: A Case Study of Resilient City Policy in Bangkok.Annals of global health · 2025Article
- Article
- Current Status and Future Directions of Artificial Intelligence in Post-Traumatic Stress Disorder: A Literature Measurement Analysis.Behavioral sciences (Basel, Switzerland) · 2024Review
- Epigenetic Modifications and Neuroplasticity in the Pathogenesis of Depression: A Focus on Early Life Stress.Behavioral sciences (Basel, Switzerland) · 2024Review
- Thematic Selection: Stress and Stress-related Disorders Neurobiology & Translational Aspects of Stress-related Disorders (Part 3).Current neuropharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to acute and chronic stress has a broad range of structural effects on the brain. The brain areas commonly targeted in the stress response models include the hippocampus, the amygdala, and the prefrontal cortex. Studies in patients suffering from the so-called stress-related disorders -embracing post-traumatic stress, major depressive and anxiety disorders- have fairly replicated animal models of stress response -particularly the neuroendocrine and the inflammatory models- by finding alterations in different brain areas, even in the early neurodevelopment. Therefore, this narrative review aims to provide an overview of structural neuroimaging findings and to discuss how these studies have contributed to our knowledge of variability in response to stress and the ulterior development of stress-related disorders. There are a gross number of studies available but neuroimaging research of stress-related disorders as a single category is still in its infancy. Although the available studies point at particular brain circuitries involved in stress and emotion regulation, the pathophysiology of these abnormalities -involving genetics, epigenetics and molecular pathways-, their relation to intraindividual stress responses -including personality characteristics, self-perception of stress conditions…-, and their potential involvement as biomarkers in diagnosis, treatment prescription and prognosis are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.