ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2023
Individual and joint associations of anxiety disorder and depression with cardiovascular disease: A UK Biobank prospective cohort study.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Biomolecular Pathways Linking Preoperative Chronic Stress to Postoperative Cardiovascular Dysfunction in Noncardiac Surgery.Biomolecules · 2026Review
- Baihe Dihuang decoction activates cannabinoid type 2 receptor to regulate microglial polarization and alleviate anxiety-like behavior in chronic restraint stress mice.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Article
- Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Interacting and joint effects of frailty and depressive symptoms in relation to risk of cardio-oncology comorbidity in older adults from three prospective cohorts.BMC geriatrics · 2026Article
- Association between depressive symptoms and atherosclerotic cardiovascular disease: a Swedish population-based cohort study.BMC cardiovascular disorders · 2026Article
- Bidirectional associations between anxiety disorders and myocardial infarction: a retrospective longitudinal cohort study.BMC cardiovascular disorders · 2026Article
- Mental health status and cardiovascular outcomes across Life's Essential 8 categories.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Association between depression and heart failure: A meta-analysis of cohort studies with 2.6 million participants.Pakistan journal of medical sciences · 2025Review
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- Refining PREVENT prediction models for 10-year risk of cardiovascular disease using measures of anxiety and depression.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease.European journal of medical research · 2024Article
- Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024Article
- Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan.Current atherosclerosis reports · 2024Review
- Association of alcohol consumption with aortic aneurysm and dissection risk: results from the UK Biobank cohort study.World journal of emergency medicine · 2024Article
- Exploring the multifaceted potential of (R)-ketamine beyond antidepressant applications.Frontiers in pharmacology · 2024Review
- "Close your eyes and relax": the role of hypnosis in reducing anxiety, and its implications for the prevention of cardiovascular diseases.Frontiers in psychology · 2024Review
- Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review.Frontiers in public health · 2024Review
- Higher atherogenic index of plasma is associated with increased major depressive disorder: insights from a nationally representative study.Frontiers in psychiatry · 2024Article
- Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms.Animal models and experimental medicine · 2023Review
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Abstract
backgroundGrowing evidence suggests that individuals with anxiety disorder have an elevated risk of cardiovascular disease (CVD) but few studies have assessed this association independently of or jointly with depression.
methodsWe conducted a prospective cohort study using UK Biobank. Diagnoses of anxiety disorder, depression, and CVDs were ascertained through linked hospital admission and mortality data. Individual and joint associations between anxiety disorder and depression and CVD overall, as well as each of myocardial infarction, stroke/transient ischemic attack, and heart failure, were analyzed using Cox proportional hazard models and interaction tests.
resultsAmong the 431,973 participants, the risk of CVD was higher among those who had been diagnosed with anxiety disorder only (hazard ratio [HR] 1.72; 95% confidence interval [CI] 1.32-2.24), depression only (HR 2.07; 95% CI 1.79-2.40), and both conditions (HR 2.89; 95% CI 2.03-4.11) compared to those without these conditions, respectively. There was very little evidence of multiplicative or additive interaction. Results were similar for myocardial infarction, stroke/transient ischemic attack, and heart failure.
conclusionsHaving anxiety is associated with the same magnitude of increased risk of CVD among people who do not have depression and those who do. Anxiety disorder should be considered for inclusion in CVD risk prediction and stratification, in addition to depression.
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