ArticleInternational wound journal2023
Risk factor analysis for diabetic foot ulcer-related amputation including Controlling Nutritional Status score and neutrophil-to-lymphocyte ratio.
Article in International wound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Hemoglobin-albumin-lymphocyte-platelet score associated with diabetic foot severity, unlike modified systemic immune-inflammatory index and modified systemic inflammatory response index.Frontiers in endocrinology · 2026Article
- Multi-Radiomics Features of Super-Resolution MRI for Predicting Minor Amputation in Wagner 3 Diabetic Foot Ulcers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association between controlling nutritional status (CONUT) score and amputation risk factors in T2DM patients with DFU.Frontiers in endocrinology · 2026Article
- Prediction of mortality risk in patients with peripheral artery disease using interpretable machine learning.Frontiers in cardiovascular medicine · 2026Article
- Preoperative neutrophil-to-lymphocyte ratio is associated with amputation level progression in patients with diabetic foot.Frontiers in surgery · 2026Article
- Clinical Severity and Systemic Inflammatory Indices as Predictors of In-Hospital Mortality After Limb Amputation a Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Exosomes from adipose-derived stem cells: A potential therapeutic strategy for diabetic foot ulcers.World journal of diabetes · 2025Review
- Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic foot infection.Archives of endocrinology and metabolism · 2025Review
- Neutrophil-lymphocyte ratio (NLR); an accurate inflammatory marker to predict diabetic foot ulcer amputation: a matched case-control study.BMC endocrine disorders · 2025Article
- Development and validation of a nomogram for predicting moderate-to-severe diabetic foot ulcers in type 2 diabetes.Frontiers in endocrinology · 2025Article
- Monocyte Count as a Predictor of Major Adverse Limb Events in Aortoiliac Revascularization.Journal of clinical medicine · 2024Article
- The relationship between dietary phytochemical index and novel anthropometric indices and the severity of diabetic foot ulcers in adults with type 2 diabetes: a cross-sectional study.BMC endocrine disorders · 2024Article
- Delayed treatment of diabetic foot ulcer in patients with type 2 diabetes and its prediction model.World journal of diabetes · 2024Article
- The impact of inflammatory biomarkers on amputation rates in patients with diabetic foot ulcers.International wound journal · 2024Article
- Risk factors for amputation in diabetic foot ulcers: A retrospective analysis.International wound journal · 2024Article
- The association of the perioperative neutrophil-to-lymphocyte ratio with wound healing in patients with Wagner grade 3 and 4 diabetic foot ulcers after tibial cortex transverse transport surgery: a prospective observational cohort study.Frontiers in endocrinology · 2024Observational
- Risk factor analysis for diabetic foot ulcer-related amputation including Controlling Nutritional Status score and neutrophil-to-lymphocyte ratio.International wound journal · 2023Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic foot ulcer often leads to amputation, and both nutritional status and immune function have been associated with this process. We aimed to investigate the risk factors of diabetic ulcer-related amputation including the Controlling Nutritional Status score and neutrophil-to-lymphocyte ratio biomarker. We evaluated data from hospital in patients with diabetic foot ulcer, performing univariate and multivariate analyses to screen for high-risk factors and Kaplan-Meier analysis to correlate high-risk factors with amputation-free survival. Overall, 389 patients underwent 247 amputations over the follow-up period. After correction to relevant variables, we identified five independent risk factors for diabetic ulcer-related amputation: ulcer severity, ulcer site, peripheral arterial disease, neutrophil-to-lymphocyte ratio and nutritional status. Amputation-free survival was lower for the moderate-to-severe versus mild cases, for the plantar forefoot versus hindfoot location, for the concomitant peripheral artery disease versus without and in the high versus low neutrophil-to-lymphocyte ratio (all p < 0.01). The results showed that ulcer severity (p < 0.01), ulcer site (p < 0.01), peripheral artery disease (p < 0.01), neutrophil-to-lymphocyte ratio (p < 0.01) and Controlling Nutritional Status score (p < 0.05) were independent risk factors for amputation in diabetic foot ulcer patients and have predictive values for diabetic foot ulcer progression to amputation.
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