ArticleJournal of veterinary internal medicine
Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Efficacy of GS-441524 for Feline Infectious Peritonitis: A Systematic Review (2018-2024).Pathogens (Basel, Switzerland) · 2025Pooled it
- A Validated Eco-Friendly High-Performance Liquid Chromatography Assay for Therapeutic Drug Monitoring of GS-441524 in Cats with Feline Infectious Peritonitis.Pathogens (Basel, Switzerland) · 2026Article
- Clinical and imaging findings after antiviral treatment in cats with presumptive neurologic feline infectious peritonitis: 9 cases (2020-2024).Journal of veterinary internal medicine · 2026Article
- Update on Treatment of Feline Infectious Peritonitis: European Advisory Board on Cat Diseases (ABCD) Guidelines.Viruses · 2026Review
- Ocular findings in cats with feline infectious peritonitis treated with GS-441524: a preliminary prospective study of 118 cases.Journal of feline medicine and surgery · 2026Article
- Treatment of non-effusive feline infectious peritonitis using oral remdesivir or GS-441524: a randomized, double-blind, non-inferiority trial.Journal of feline medicine and surgery · 2026Article
- Therapeutic Drug Monitoring of GS-441524 in Cats with Feline Infectious Peritonitis: Pharmacokinetic Variability and Implications for Dose Optimization.Pathogens (Basel, Switzerland) · 2026Article
- Nucleoside analogue EIDD-1931 in the treatment of naturally occurring feline infectious peritonitis.Journal of feline medicine and surgery · 2026Article
- Albumin/Globulin ratio as a valuable marker for monitoring remdesivir therapy in feline infectious peritonitis.Open veterinary journal · 2026Article
- Feline Peritoneal Effusions-A Poor Prognosis?Animals : an open access journal from MDPI · 2025Article
- Identification and characterization of a nonpeptidic cyclophilin ligand with antiviral activity against feline and porcine α-coronaviruses.Veterinary research · 2025Article
- Clinical therapeutics in feline medicine: updates for old and new drugs.Journal of feline medicine and surgery · 2025Review
- Article
- From Challenge to Cure: A Look at Feline Infectious Peritonitis and Emerging Treatment Strategies and Breakthroughs.Veterinary sciences · 2025Review
- Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and Their Housemates.Viruses · 2025Article
- Pharmacokinetics of GS-441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021-2024).The Journal of small animal practice · 2025Article
- Comparative transcriptome analysis of PBMCs in cats diagnosed with and recovered from FIPV.Laboratory animal research · 2025Article
- Myocarditis in Cats with Feline Infectious Peritonitis Can Be Cured with GS-441524 and Symptomatic Cardiovascular Treatment.Animals : an open access journal from MDPI · 2025Article
- Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524.Pathogens (Basel, Switzerland) · 2025Article
- Evaluation of selected inflammatory markers in cats with feline infectious peritonitis before and after therapy.BMC veterinary research · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGS-441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. However, the use of its prodrug, remdesivir, in combination with a PO GS-441524 containing product for the treatment of FIP has not yet been described.
objectivesDescribe treatment protocols, response to treatment and outcomes in cats with FIP treated with a combination of PO GS-441524 and injectable remdesivir. ANIMALS: Thirty-two client-owned cats diagnosed with effusive or non-effusive FIP including those with ocular and neurological involvement.
methodsCats diagnosed with FIP at a single university hospital between August 2021 and July 2022 were included. Variables were recorded from time of diagnosis, and subsequent follow-up information was obtained from the records of referring veterinarians. All surviving cats were observed for the entire 12-week treatment period.
resultsCats received treatment with different combinations of IV remdesivir, SC remdesivir, and PO GS-441524 at a median (range) dosage of 15 (10-20) mg/kg. Clinical response to treatment was observed in 28 of 32 cats (87.5%) in a median (range) of 2 (1-5) days. Twenty-six of 32 cats (81.3%) were alive and in clinical and biochemical remission at the end of the 12-week treatment period. Six of 32 cats (18.8%) died or were euthanized during treatment with 4 of the 6 cats (66%) dying within 3 days of starting treatment.
conclusionsWe describe the effective use of injectable remdesivir and PO GS-441524 for the treatment of FIP in cats. Success occurred using different treatment protocols and with different presentations of FIP including cats with ocular and neurological involvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.