Evidence map›Paper›PMID 37403134›Full record

ArticleAntimicrobial resistance and infection control2023

Tolerance of clinical vancomycin-resistant Enterococcus faecium isolates against UV-C light from a mobile source.

B Knobling, G Franke, C Belmar Campos, H Büttner, M Christner, E M Klupp, P M Maurer, J K Knobloch

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Article in Antimicrobial resistance and infection control, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

B KnoblingInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
G FrankeInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
C Belmar CamposInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
H BüttnerInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
M ChristnerInstitute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
E M KluppInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
P M MaurerInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J K KnoblochInstitute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. j.knobloch@uke.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdmission to a room previously occupied by patients carrying environmentally robust pathogens implies an increased risk of acquiring those pathogens. Therefore, 'No-touch' automated room disinfection systems, including devices based on UV-C irradiation, are discussed to improve terminal cleaning. It is still unclear if clinical isolates of relevant pathogens behave differently under UV-C irradiation compared to laboratory strains used in the approval process of disinfection procedures. In this study we analysed the susceptibility of well characterized clonally divergent vancomycin-resistant enterococci (VRE) strains, including a linezolid-resistant isolate, against UV-C radiation.

methodsSusceptibility against UV-C of ten clonally divergent clinical isolates of VRE was determined in comparison to the commonly used test organism Enterococcus hirae ATCC 10541. Ceramic tiles contaminated with 10

resultsSusceptibility to UV-C varied considerably among the strains studied, with the mean value of the most robust strain being up to a power of ten lower compared to the most sensitive strain at both UV-C doses. The two most tolerant strains belonged to MLST sequence types ST80 and ST1283. The susceptibility of the laboratory strain E. hirae ATCC 10541 ranged between the most sensitive and most tolerant isolates for both irradiation doses. However, for UV-C dose of 22 mJ/cm², the reduction of the most tolerant isolate of ST1283 was statistically significantly lower compared to E. hirae ATCC 10541. The most susceptible strains belonged to the MLST sequence types ST117 and ST203.

conclusionsThese results indicate that UV-C doses reported in the literature are sufficient for the reduction of commonly used reference strains of enterococci but could be insufficient for the reduction of tolerant patient VRE-isolates in a hospital setting. Therefore, for future studies, the most tolerant clinical isolates should be used to validate automated UV-C devices or longer exposure times should be expected to ensure efficacy in the real world.

Indexed as

Enterococcus faeciumGram-Positive Bacterial InfectionsVancomycin-Resistant EnterococciHumansMultilocus Sequence TypingVancomycinVancomycinAutomatic room decontaminationDisinfectionUV-CUV-irradiationvancomycin resistant enterococci

Identifiers

PMID37403134
PMCPMC10320914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.