Evidence map›Paper›PMID 37402978›Full record

SynthesisDigestive diseases and sciences2023

A Systematic Review and Meta-Analysis: A Prior Appendectomy Does Not Increase the Risk of Severe Clostridioides difficile Infection or Recurrence.

Yassin Shams Eldien Naga, Banreet Singh Dhindsa, Jay Bapaye, Kyaw Min Tun, Amaninder Dhaliwal, Daryl Ramai, Syed Mohsin Saghir, Saurabh Chandan, Douglas G Adler

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Yassin Shams Eldien NagaDepartment of Internal Medicine, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.
Banreet Singh DhindsaDivision of Gastroenterology and Hepatology, University of Nebraska Medical Center, 982000 Nebraska Medical Center, Omaha, NE, 68198-2000, USA.
Jay BapayeDepartment of Internal Medicine, Rochester Regional Health, 1425 Portland Avenue, Rochester, NY, 14621, USA.
Kyaw Min TunDepartment of Internal Medicine, University of Nevada Las Vegas School of Medicine, 1701 W Charleston Blvd., Las Vegas, NV, 89102, USA.
Amaninder DhaliwalDivision of Gastroenterology and Hepatology, McLeod Regional Medical Center, Florence, SC, 29506, USA.
Daryl RamaiDivision of Gastroenterology and Hepatology, University of Utah School of Medicine, 30 N 1900 E, Room 4R118, Salt Lake City, UT, 84132, USA.
Syed Mohsin SaghirDivision of Gastroenterology and Hepatology, Creighton University School of Medicine, Omaha, NE, 68124, USA.
Saurabh ChandanDivision of Gastroenterology and Hepatology, Creighton University School of Medicine, Omaha, NE, 68124, USA.
Douglas G AdlerCenter for Advanced Therapeutic Endoscopy, Centura Health, Denver, CO, USA. dougraham2001@gmail.com.ORCID 0000-0003-3214-6285
Creighton University · USDenver Health Medical Center · USOrlando Regional Medical Center · USUnity Health System · USUniversity of Nebraska Medical Center · USUniversity of Nevada, Las Vegas · USUniversity of South Florida · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThere is conflicting evidence regarding the association between a prior appendectomy and severity of Clostridioides difficile infection. The aim of this study was to perform a systematic review and meta-analysis to evaluate this association. PATIENTS AND

methodsComprehensive review of multiple databases was performed up to May 2022. The primary outcome assessed was the rate of severe Clostridioides difficile infection in patients with a prior appendectomy compared to patients with an appendix. The secondary outcomes assessed were recurrence, mortality, and colectomy rates associated with Clostridioides difficile infection in patients with a prior appendectomy compared to patients with an appendix.

resultsEight studies with 666 patients with a prior appendectomy and 3580 patients without an appendectomy were included. The odds ratio of severe Clostridioides difficile infection in patients who underwent prior appendectomy was 1.03 (95% CI 0.6-1.78, p = 0.92). The odds ratio of recurrence in patients who underwent prior appendectomy was 1.29 (95% CI 0.82-2.02, p = 0.28). The odds ratio of colectomy due to Clostridioides difficile infection in patients who underwent prior appendectomy was 2.16 (95% CI 1.27-3.67, p = 0.004). The odds ratio of mortality due to Clostridioides difficile infection in patients with a prior appendectomy was 0.92 (95% CI 0.62-1.37, p = 0.68).

conclusionPatients with appendectomy are not at increased risk for developing severe Clostridioides difficile infection or recurrence. Further prospective studies are needed to establish these associations.

Indexed as

Clostridioides difficileClostridium InfectionsAppendectomyColectomyHumansProspective StudiesRecurrenceAppendectomyClostridioides difficileMeta-analysisSeverity

Identifiers

PMID37402978
OpenAlexW4383187553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.