Evidence map›Paper›PMID 37402854›Full record

ArticleMolecular psychiatry2023

Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca

Tristen Hewitt, Begüm Alural, Manali Tilak, Jennifer Wang, Natalina Becke, Ellis Chartley, Melissa Perreault, Stephen J Haggarty, Steven D Sheridan, Roy H Perlis and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Bipolar Disorder.Current opinion in neurobiology · 2023
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Tristen Hewitt *Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Begüm Alural *Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Manali TilakDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Jennifer WangCenter for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID 0000-0002-4195-376X
Natalina BeckeDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Ellis ChartleyDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Melissa PerreaultDepartment of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-5775-8950
Stephen J HaggartyCenter for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID 0000-0002-7872-168X
Steven D SheridanCenter for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID 0000-0003-1045-1158
Roy H PerlisCenter for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.
Nina JonesDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Nikolaos MelliosDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.ORCID 0000-0002-0310-1144
Jasmin LalondeDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada. jlalon07@uoguelph.ca.ORCID 0000-0002-6797-1894
University of Guelph · CAMassachusetts General Hospital · USUniversity of Helsinki · FIUniversity of New Mexico · US

Funding

Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 24990
6 · The paper itself

Abstract

While most of the efforts to uncover mechanisms contributing to bipolar disorder (BD) focused on phenotypes at the mature neuron stage, little research has considered events that may occur during earlier timepoints of neurodevelopment. Further, although aberrant calcium (Ca

Indexed as

Bipolar DisorderCalciumCalcium SignalingCell DifferentiationInduced Pluripotent Stem CellsNeural Stem CellsNeuronsFemaleHumansMaleMicroRNAsNeurogenesisOrganoidsTranscriptomeCalciumMicroRNAs

Identifiers

PMID37402854
PMCPMC11041787
OpenAlexW4383101989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.