Observational studyEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2023
Hypoalbuminemia: incidence and its impact on acute respiratory distress syndrome and 28-day outcome in trauma patients.
Observational study in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Serum Albumin Level at Intensive Care Unit Admission and Delirium Duration and Severity in Critically Ill Adults.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2024Trial
- Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and HALP Score as Predictors of Mortality in Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2026Article
- Relationship between red cell distribution width to albumin ratio (RAR) and mortality in ICU patients with sepsis-associated ARDS: a retrospective study based on MIMIC-IV.BMC infectious diseases · 2026Article
- Albuminemia as a Potential Predictor of Clinical Outcomes in Patients with Severe Traumatic Brain Injury (TBI).Journal of clinical medicine · 2025Article
- Risk factors for postoperative pulmonary complications following coronary artery bypass grafting in elderly patients: a retrospective study.Journal of cardiothoracic surgery · 2025Article
- Establishment and validation of a 28-day mortality prediction model based on the lactate dehydrogenase/albumin ratio in patients with severe pneumonia.Frontiers in medicine · 2025Article
- A Simple Nomogram for Predicting the Development of ARDS in Postoperative Patients with Gastrointestinal Perforation: A Single-Center Retrospective Study.Journal of inflammation research · 2025Article
- Is it time to Reassess The Role of Preoperative HypoalbuminemiaAmong Geriatric Distal Femur Fracture Patients?Archives of orthopaedic and trauma surgery · 2024Article
- Early predictive values of clinical assessments for ARDS mortality: a machine-learning approach.Scientific reports · 2024Observational
- Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders.Diagnostics (Basel, Switzerland) · 2024Article
- Tiny Guides, Big Impact: Focus on the Opportunities and Challenges of miR-Based Treatments for ARDS.International journal of molecular sciences · 2024Review
- Low Prognostic Nutritional Index (PNI) Level is Associated with an Increased Risk of Neonatal Respiratory Distress Syndrome in Preterm Infants with Different Gestational Ages: A Retrospective Study.International journal of general medicine · 2024Article
- Critical Appraisal and Future Directions for the Association Between Albumin Levels and Neonatal Acute Respiratory Distress Syndrome in Newborn Pneumoniae [Letter].Journal of inflammation research · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis prospective observational study explored the effect of early onset hypoalbuminemia (EOH) on the development of adult respiratory distress syndrome (ARDS) in orthopedic trauma victims.
methodsSerum albumin levels were measured for the initial 7 days of injury for adult trauma patients (18-65 years). Patients were recruited into group A (any serum albumin value < 3.5 mg/dl) and group B (all serum albumin ≥ 3.5 mg/dl), based on serum albumin values. Patients were followed for the development of ARDS and outcome until 28 days. The primary outcome of the study was to explore the effects of EOH on ARDS.
resultsEOH (any serum albumin value < 3.5 g/dl within 7 days of injury) was present in 205/386 (53.1%) patients. The majority of 174/205 (84.9%) patients had EOH by the fourth day after the injury, with the mean time for development of EOH being 2.15 ± 1.87 days. ARDS manifested in 87/205 (42.4%) and 15/181 (8.3%) patients in group A and group B, respectively (p < 0.001). EOH had 8.2 times greater odds of ARDS (OD 8.2 95% CL 4.7-14.0, p = 0.000). The mean time for the onset of ARDS was 5.63 ± 2.62 days. No statistically significant causal relationship occurred between the onset of EOH and the development of ARDS (Pearson's correlation coefficient = 0.14, p = 0.16). At serum albumin cutoff concentrations of 3.4 gm/dl on D1 (AUC 0.68, 95% CI: 0.61-0.74, p = 0.000), ARDS may be anticipated in 62.8% of patients. The commencement of ARDS was independently correlated with EOH (p = 0.000), Respiratory rate on admission (p = 0.000), inotrope use (p = 0.000), and soft tissue injury (p = 0.000) (R
conclusionEOH is a frequent occurrence and has a strong influence development of ARDS and 28-day mortality in trauma patients.
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