Evidence map›Paper›PMID 37402485›Full record

ArticleFEBS open bio2023

HPV18 E6 inhibits α-ketoglutarate-induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway.

Duo Tang, Yuchen Zheng, Guozhen Wang, Chao Sheng, Zijia Liu, Biqi Wang, Qi Zong, Yuchen Zhang, Xiaonan Hou, Mengfei Yao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Role of gasdermins in chronic kidney disease.Frontiers in immunology · 2025
    Review
  5. Article
  6. Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Duo TangBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.ORCID 0000-0001-9790-7431
Yuchen ZhengBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Guozhen WangBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Chao ShengBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Zijia LiuBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Biqi WangBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Qi ZongBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Yuchen ZhangBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Xiaonan HouBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Mengfei YaoBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Zhixiang ZhouBeijing International Science and Technology Cooperation Base of Antivirus Drug, Department of Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Beijing University of Technology · CNChina-Japan Friendship Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncogene E6 plays a critical role in the development and progression of esophageal cancer caused by human papillomavirus (HPV) infection. Alpha-ketoglutarate (AKG) is a key metabolite in the tricarboxylic acid cycle and has been widely used as a dietary and anti-ageing supplement. In this study, we found that treating esophageal squamous carcinoma cells with a high dose of AKG can induce cell pyroptosis. Furthermore, our research confirms that HPV18 E6 inhibits AKG-induced pyroptosis of esophageal squamous carcinoma cells by lowering P53 expression. P53 downregulates malate dehydrogenase 1 (MDH1) expression; however, MDH1 downregulates L-2-hydroxyglutarate (L-2HG) expression, which inhibits a rise in reactive oxygen species (ROS) levels-as L-2HG is responsible for excessive ROS. This study reveals the actuating mechanism behind cell pyroptosis of esophageal squamous carcinoma cells induced by high concentrations of AKG, and we posit the molecular pathway via which the HPV E6 oncoprotein inhibits cell pyroptosis.

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaOncogene Proteins, ViralPapillomavirus InfectionsBiomarkers, TumorGasderminsHuman papillomavirus 18HumansKetoglutaric AcidsPore Forming Cytotoxic ProteinsPyroptosisReactive Oxygen SpeciesTumor Suppressor Protein p53Biomarkers, TumorGasderminsGSDMC protein, humanKetoglutaric AcidsOncogene Proteins, ViralPore Forming Cytotoxic ProteinsReactive Oxygen SpeciesTumor Suppressor Protein p53E6 oncogeneGSDMCHPVpyroptosisROSα-ketoglutarate

Identifiers

PMID37402485
PMCPMC10392054
OpenAlexW4383105829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.