ArticleCell reports2023
Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma.
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In one paragraph
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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0cells of the map it votes in
28citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
What it found
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Pathophysiological roles of monocytes and macrophages in cancer.Nature reviews. Immunology · 2026Review
- Review
- Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer.Cancer immunology research · 2026Article
- Reduced Tumor Control in Males Can Result from Impaired CD4+ T-cell Help through the CD40L-CD40 Pathway.Cancer immunology research · 2026Article
- Pancreatic ductal adenocarcinoma: integrating molecular insights for targeted interventions.Signal transduction and targeted therapy · 2026Review
- Therapeutic targeting of RAGE/STAT3 signaling abrogates S100A7-driven breast tumorigenicity and immune suppression.Breast cancer research : BCR · 2026Article
- Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment.Nature reviews. Cancer · 2026Review
- Article
- Hypoxia-driven remodeling of SELENOPNature communications · 2026Article
- CD4+ T Cells Mediate MHC-Deficient Tumor Rejection and Endothelial Cell Reprogramming.Cancer immunology research · 2026Article
- mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics.Cancer innovation · 2025Review
- Positive and negative roles of myeloid cells in cancer immunotherapy.Journal for immunotherapy of cancer · 2025Review
- Polarization of Tumor Cells and Tumor-Associated Macrophages: Molecular Mechanisms and Therapeutic Targets.MedComm · 2025Review
- Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.Science immunology · 2025Article
- IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma.Cancer immunology research · 2025Article
- Facts and Hopes of CD40 Agonists in Cancer Immunotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Review
- FOLR2Cell communication and signaling : CCS · 2025Review
- Tumor-associated macrophages (TAMs): Constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC).Cancer pathogenesis and therapy · 2025Review
- Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.Nature communications · 2025Article
- Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Michael T PattersonCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55414, USA.
Adam L BurrackCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Yingzheng XuCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55414, USA.
Grant H HickokCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Zoe C SchmiechenCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Samuel BeckerCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Eduardo Cruz-HinojozaCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Patricia R SchrankCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55414, USA.
Ainsley E KennedyCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55414, USA.
Maria M FirulyovaComputer Technologies Laboratory, ITMO University, Saint-Petersburg, Russia; National Medical Research Center, Saint-Petersburg, Russia.
Ebony A MillerCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Konstantin ZaitsevComputer Technologies Laboratory, ITMO University, Saint-Petersburg, Russia.
Jesse W WilliamsCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55414, USA. Electronic address: jww@umn.edu.
Ingunn M StromnesCenter for Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA; Masonic Cancer Center and University of Minnesota Medical School, Minneapolis, MN 55414, USA; Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, MN 55414, USA. Electronic address: ingunn@umn.edu.
University of Minnesota · USITMO University · RU
Funding
Project 3P01CA254849 · NCI · UNIVERSITY OF MINNESOTA · PI PROVENZANO, PAOLO · 2021 to 2025
$9.4MTraining Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MSex and stress hormones control adrenal gland macrophage development and function"R01AI165553 · NIAID · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2022 to 2025
$2.2MMechanisms of immunotherapy response and resistance in pancreatic ductal adenocarcinomaR01CA249393 · NCI · UNIVERSITY OF MINNESOTA · PI STROMNES, INGUNN MARGARETE · 2021 to 2025
$2.1MEnhancing engineered T cell therapeutic efficacy for the treatment of pancreatic ductal adenocarcinomaR01CA255039 · NCI · UNIVERSITY OF MINNESOTA · PI STROMNES, INGUNN MARGARETE · 2021 to 2025
$2.0MElucidating the Role of Tregs in Cancer Metastasis and T Cell DysfunctionF31CA275289 · NCI · UNIVERSITY OF MINNESOTA · PI SCHMIECHEN, ZOE · 2023 to 2024
$67kNCI NIH HHS F31 CA275289NCI NIH HHS P01 CA254849NCI NIH HHS R01 CA249393NCI NIH HHS R01 CA255039NIAID NIH HHS R01 AI165553NIAID NIH HHS T32 AI007313NIA NIH HHS T32 AG029796
Abstract
Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, by employing macrophage fate-mapping approaches and single-cell RNA sequencing, we show that monocytes give rise to most macrophage subsets in PDA. Tumor-specific CD4, but not CD8, T cells promote monocyte differentiation into MHCII
Indexed as
Carcinoma, Pancreatic DuctalPancreatic NeoplasmsAntigens, NeoplasmCD4-Positive T-LymphocytesHistocompatibility Antigens Class IIHumansMonocytesTumor MicroenvironmentAntigens, NeoplasmHistocompatibility Antigens Class IICCR2CD40CD4 T cellsCP: CancerCP: ImmunologyIFNgimmunotherapymacrophagepancreatic cancerPDAPD-L1T cells
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.