Evidence map›Paper›PMID 37402091›Full record

ArticleJournal of neuro-oncology2023

Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.

Maher Kurdi, Motaz M Fadul, Bassam M J Addas, Eyad Faizo, Shadi Alkhayyat, Ahmed K Bamaga, Taghreed Alsinani, Yousef Katib, Fahad Okal, Yazid Maghrabi and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Maher KurdiDepartment of Pathology, Faculty of Medicine, King Abdulaziz University, Rabigh, Kingdom of Saudi Arabia. Ahkurdi@kau.edu.sa.ORCID http://orcid.org/0000-0002-8979-3849
Motaz M FadulDepartment of Pathology, Faculty of Medicine, King Abdulaziz University, Rabigh, Kingdom of Saudi Arabia.
Bassam M J AddasDepartment of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Eyad FaizoDepartment of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Shadi AlkhayyatDepartment of Internal Medicine, Faculty of Medicine, King Abdulaziz University and Hospital, Jeddah, Saudi Arabia.
Ahmed K BamagaDepartment of Paediatric, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Taghreed AlsinaniDepartment of Neurosurgery, King Fahad General Hospital, Jeddah, Saudi Arabia.
Yousef KatibDepartment of Radiology, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.
Fahad OkalDepartment of Neuroscience, Neurosurgery Section, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia.
Yazid MaghrabiDepartment of Neuroscience, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Abdulrahman J SabbaghDepartment of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Rana MoshrefDepartment of Neuroscience, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Sultan AlbalawiDepartment of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Alaa AlkhotaniDepartment of Pathology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Taher F HalawaDepartment of Paediatric, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia.
Nasser MullaDepartment of Internal Medicine, Faculty of Medicine, Taibah University, Medina, Saudi Arabia.
Sahar HakamyNeuromuscular Unit, King Fahad Medical Research Center, Jeddah, Saudi Arabia.
Saleh BaeesaDepartment of Neuroscience, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
King Abdulaziz University · SAKing Faisal Specialist Hospital & Research Centre · SAKing Fahad Hospital Jeddah · SATaibah University · SAKing Abdulaziz Medical City · SAUmm al-Qura University · SAUniversity of Tabuk · SA

Funding

King Abdulaziz University IFPIP: 348-828-1443
6 · The paper itself

Abstract

backgroundCorticosteroid is commonly used before surgery to control cerebral oedema in brain tumours and is frequently continued throughout treatment. Its long-term effect of on the recurrence of WHO-Grade 4 astrocytoma remains controversial. The interaction between corticosteroid, SRC-1 gene and cytotoxic T-cells has never been investigated.

methodsA retrospective cohort of 36 patients with WHO-Grade 4 astrocytoma were examined for CD8 + T-cell and SRC-1 gene expressions through IHC and qRT-PCR. The impact of corticosteroid on CD8

resultsThe mean patients age was 47-years, with a male to female ratio 1.2. About 78% [n = 28] of the cases showed reduced or no CD8

conclusionsCorticosteroid treatment can directly affect the SRC-1 gene regulation but does not directly influence cytotoxic T-cells infiltration or tumor progression. However, SRC-1 gene downregulation can facilitate late tumor recurrence.

Indexed as

AstrocytomaGlioblastomaNuclear Receptor Coactivator 1Adrenal Cortex HormonesFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesWorld Health OrganizationAdrenal Cortex HormonesNCOA1 protein, humanNuclear Receptor Coactivator 1CD8CorticosteroidSRC-1T-cellsWHO Grade 4 Astrocytoma

Identifiers

PMID37402091
PMCPMC10393858
OpenAlexW4383059072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.