Evidence map›Paper›PMID 37401993›Full record

Trial reportAIDS and behavior2023

Adherence to Antiretrovirals and HIV Viral Suppression Under COVID-19 Pandemic Interruption - Findings from a Randomized Clinical Trial Using Ingestible Sensors to Monitor Adherence.

Yan Wang, Eric S Daar, Yilan Huang, Di Xiong, Jie Shen, Linyu Zhou, Lisa Siqueiros, Mario Guerrero, Marc I Rosen, Honghu Liu

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02797262 (Measuring and Monitoring Adherence to ART With Pill Ingestible Sensor System), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02797262 nacompletednot on this map

Measuring and Monitoring Adherence to ART With Pill Ingestible Sensor System

TypeinterventionalSponsorUniversity of California, Los AngelesRan2015 to 2020Enrolled130ConditionsHIV/AIDS, Medication AdherenceArmsProteus digital health feedback (PDHF) system
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yan WangSection of Public and Population Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA. wangyan@ucla.edu.ORCID http://orcid.org/0000-0002-4822-6514
Eric S DaarDepartment of Medicine, Division of HIV Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yilan HuangDepartment of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
Di XiongDepartment of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
Jie ShenSection of Public and Population Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Linyu ZhouDepartment of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
Lisa SiqueirosDepartment of Medicine, Division of HIV Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Mario GuerreroDepartment of Medicine, Division of HIV Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Marc I RosenSchool of Medicine, Yale University, New Haven, Connecticut, USA.
Honghu LiuSection of Public and Population Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
UCLA Medical Center · USUniversity of California, Los Angeles · USYale University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
Measuring and Monitoring Adherence to ART with Pill Ingestion Sensor SystemR01MH110056 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAAR, ERIC S, LIU, HONGHU · 2015 to 2019
$4.0M
NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1TR001881NIMH NIH HHS R01 MH110056NIMH NIH HHS R01-MH110056NIMH NIH HHS T32 MH080634NIMH NIH HHS T32MH080634
6 · The paper itself

Abstract

The COVID-19 pandemic had a significant impact on vulnerable populations, including people living with HIV. California implemented a coronavirus lockdown (stay-at-home order) in March 2020, which ended in January 2021. We evaluated the pandemic's impact on both clinical outcomes of HIV RNA viral load (VL) and retention rate in a randomized clinical trial conducted from May 2018 to October 2020. The intervention group took co-encapsulated antiretrovirals (ARVs) with ingestible sensor (IS) pills from baseline through week 16. The IS system has the capacity to monitor adherence in real-time using a sensor patch, a mobile device, and supporting software. Both the IS and usual care (UC) groups were followed monthly for 28 weeks. Longitudinal mixed-effects models with random intercept and slope (RIAS) were used to fit log VL and self-reported adherence. The sample size of the study was 112 (54 in IS). Overall, the retention rate at week 28 was 86%, with 90% before the lockdown and 83% after the lockdown. The lockdown strengthened the associations between adherence and VL. Before the lockdown, a 10% increase in adherence was associated with a 0.2 unit decrease in log VL (β = -1.88, p = 0.004), while during the lockdown, the association was a 0.41-unit decrease (β = -2.27, p = 0.03). The pandemic did not have a significant impact on our adherence-focused intervention. Our findings regarding the intervention effect remain valid. TRIAL REGISTRATION NUMBER: NCT02797262. Date registration: September 2015.

Indexed as

COVID-19HIV InfectionsAnti-Retroviral AgentsCommunicable Disease ControlHumansMedication AdherencePandemicsViral LoadAnti-Retroviral AgentsAdherenceHIVIngestible sensorLockdownThe COVID-19 pandemicViral load

Identifiers

PMID37401993
PMCPMC10598162
OpenAlexW4383058936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.