Evidence map›Paper›PMID 37401734›Full record

ArticleJournal of neuroscience research2023

Alcohol cue reactivity in the brain: Age-related differences in the role of social processes in addiction in male drinkers.

Lauren Kuhns, Gabry Mies, Emese Kroon, Ingo Willuhn, Heidi Lesscher, Janna Cousijn

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuroscience research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Lauren KuhnsNeuroscience of Addiction (NofA) Lab, Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Gabry MiesNeuroscience of Addiction (NofA) Lab, Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Emese KroonNeuroscience of Addiction (NofA) Lab, Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1803-9336
Ingo WilluhnThe Amsterdam Brain and Cognition Center (ABC), University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-6540-6894
Heidi LesscherDepartment of Population Health Sciences, Unit Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Janna CousijnNeuroscience of Addiction (NofA) Lab, Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam Neuroscience · NLAmsterdam Institute for Addiction Research · NLNetherlands Institute for Neuroscience · NLRadboud University Nijmegen · NLUtrecht University · NL

Funding

The Role of Motivation and Control in Cannabis Use Disorders: A Cross-Cultural Longitudinal Neuroimaging StudyR01DA042490 · NIDA · UNIVERSITY OF TEXAS DALLAS · PI COUSIJN, JANNA, FILBEY, FRANCESCA · 2017 to 2021
$2.6M
NIDA NIH HHS R01 DA042490
6 · The paper itself

Abstract

Social attunement (SA)-the tendency to harmonize behavior with the social environment-has been proposed to drive the escalation of alcohol use in adolescence, while reducing use in adulthood. Little is known about how heightened social sensitivity in adolescence may interact with neural alcohol cue reactivity-a marker of alcohol use disorder-and its relationship to alcohol use severity over time. The aims of this study were to test whether (1) adolescents and adults differ in social alcohol cue reactivity in the nucleus accumbens, anterior cingulate cortex, and right medial prefrontal cortex (mPFC), and (2) age moderates the relationship between social alcohol cue reactivity and social attunement, measures of drinking at baseline, and changes in drinking over time. A sample of male adolescents (16-18 years) and adults (29-35 years) completed an fMRI social alcohol cue-exposure task at baseline and an online follow-up two to three years later. No main effects of age or drinking measures were observed in social alcohol cue reactivity. However, age significantly moderated associations of social alcohol cue reactivity in the mPFC and additional regions from exploratory whole-brain analyses with SA, with a positive association in adolescents and negative association in adults. Significant age interactions emerged only for SA in predicting drinking over time. Adolescents with higher SA scores escalated drinking, while adults with higher SA scores reduced drinking. These findings warrant further research on SA as a risk and protective factor and suggest that social processes influence cue reactivity differentially in male adolescents and adults.

Indexed as

AlcoholismCuesAdolescentAdultAlcohol DrinkingBrainEthanolHumansMagnetic Resonance ImagingMaleEthanoladolescencecue reactivityfMRIsocial processes

Identifiers

PMID37401734
PMCPMC10538438
OpenAlexW4383059037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.