Evidence map›Paper›PMID 37401417›Full record

ArticleCardiology journal2024

Impact of calcification on Murray law-based quantitative flow ratio for physiological assessment of intermediate coronary stenoses.

Wenjie Zuo, Renhua Sun, Yang Xu, Zhenjun Ji, Rui Zhang, Xiaoguo Zhang, Shengxian Tu, Genshan Ma

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In one paragraph

Article in Cardiology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjie ZuoDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.ORCID 0000-0002-8289-5113
Renhua SunDepartment of Cardiology, The First People's Hospital of Yancheng, Yancheng, China.
Yang XuDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Zhenjun JiDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Rui ZhangDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Xiaoguo ZhangDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Shengxian TuMed-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Genshan MaDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China. magenshan@seu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the influence of coronary calcification on the diagnostic performance of Murray law-based quantitative flow ratio (μQFR) in identifying hemodynamically significant coronary lesions referenced to fractional flow reserve (FFR).

methodsA total of 571 intermediate lesions from 534 consecutive patients (66.1 ± 10.0 years, 67.2% males) who underwent coronary angiography and simultaneous FFR measurement were included. Calcific deposits were graded by angiography as none or mild (spots), moderate (involving ≤ 50% of the reference vessel diameter), and severe (> 50%). Performance of μQFR to detect functional ischemia (FFR ≤ 0.80) was evaluated, including diagnostic parameters and areas under the receiver-operating curves (AUCs).

resultsThe discrimination of ischemia by μQFR was comparable between none/mild and moderate/severe calcification (AUC: 0.91 [95% confidence interval: 0.88-0.93] vs. 0.87 [95% confidence interval: 0.78-0.94]; p = 0.442). No statistically significant difference was observed for μQFR between the two categories in sensitivity (0.70 vs. 0.69, p = 0.861) and specificity (0.94 vs. 0.90, p = 0.192). Moreover, μQFR showed significantly higher AUCs than quantitative coronary angiographic diameter stenosis in both vessels with none/mild (0.91 vs. 0.78, p < 0.001) and moderate/severe calcification (0.87 vs. 0.69, p < 0.001). By multivariable analysis, there was no association between calcification and μQFR-FFR discordance (adjusted odds ratio: 1.529, 95% confidence interval: 0.788-2.968, p = 0.210) after adjustment for other confounding factors.

conclusionsμQFR demonstrated robust and superior diagnostic performance for lesion-specific ischemia compared with angiography alone regardless of coronary calcification.

Indexed as

Coronary AngiographyCoronary StenosisCoronary VesselsFractional Flow Reserve, MyocardialSeverity of Illness IndexVascular CalcificationAgedCardiac CatheterizationFemaleHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesROC Curvecalcificationcoronary artery diseasediagnosisfractional flow reservequantitative flow ratio

Identifiers

PMID37401417
PMCPMC11076030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.