ArticleAnnals of clinical and translational neurology2023
HLA in isolated REM sleep behavior disorder and Lewy body dementia.
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Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
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5 citing papers in PubMed, 8 citations in OpenAlex.
- Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study.NPJ Parkinson's disease · 2026Article
- Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.Annals of neurology · 2026Article
- MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation.Scientific reports · 2025Article
- From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease.Molecular neurodegeneration · 2025Review
- The Genetic Basis of Probable REM Sleep Behavior Disorder in Parkinson's Disease.Brain sciences · 2023Article
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Authors and funding
44 authors at 20 institutions in 9 countries.
Eric YuDepartment of Human Genetics, McGill University, Montréal, Québec, Canada.ORCID 0000-0003-3525-4564
Lynne KrohnDepartment of Human Genetics, McGill University, Montréal, Québec, Canada.ORCID 0000-0001-6554-1666
Jennifer A RuskeyThe Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
Farnaz AsayeshThe Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
Dan SpiegelmanThe Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
Zalak ShahNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Ruth ChiaNeuromuscular Diseases Research Section, National Institute on Aging, Bethesda, Maryland, USA.
Isabelle ArnulfSleep Disorders Unit, Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, Paris, France.
Michele T M HuOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Jacques Y MontplaisirCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
Jean-François GagnonCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
Alex DesautelsCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
Yves DauvilliersNational Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, Montpellier, France.ORCID 0000-0003-0683-6506
Gian Luigi GigliClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Mariarosaria ValenteClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Francesco JanesClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Andrea BernardiniClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.ORCID 0000-0002-0227-0659
Birgit HöglSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Ambra StefaniSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-4259-8824
Abubaker IbrahimSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Anna HeidbrederDepartment for Sleep Medicine and Neuromuscular disease, University Hospital Muenster, Muenster, Germany.
Karel SonkaDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Petr DusekDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
David KemlinkDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Wolfgang OertelDepartment of Neurology, Philipps University, Marburg, Germany.
Annette JanzenDepartment of Neurology, Philipps University, Marburg, Germany.ORCID 0000-0001-8907-5831
Giuseppe PlazziDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Modena, Italy.
Elena AntelmiNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID 0000-0003-1739-6139
Michela FigorilliDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Monica PulighedduDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Brit MollenhauerParacelsus-Elena-Klinik, Kassel, Germany.
Claudia TrenkwalderParacelsus-Elena-Klinik, Kassel, Germany.
Friederike Sixel-DöringDepartment of Neurology, Philipps University, Marburg, Germany.
Valérie Cochen De CockSleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France.ORCID 0000-0002-6460-4319
Luigi Ferini-StrambiDepartment of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy.ORCID 0000-0003-2867-5424
Femke DijkstraLaboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium.
Mineke ViaeneLaboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium.
Beatriz AbrilSleep disorder Unit, Carémeau Hospital, University Hospital of Nîmes, Nîmes, France.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Guy A RouleauDepartment of Human Genetics, McGill University, Montréal, Québec, Canada.ORCID 0000-0001-8403-1418
Ronald B PostumaThe Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.ORCID 0000-0002-6468-4734
International LBD Genomics Consortium
Sonja W ScholzNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.ORCID 0000-0002-6623-0429
Ziv Gan-OrDepartment of Human Genetics, McGill University, Montréal, Québec, Canada.ORCID 0000-0003-0332-234X
Montreal Neurological Institute and Hospital · CAUniversity of Udine · ITCharles University · CZInnsbruck Medical University · ATPhilipps University of Marburg · DEHôpital du Sacré-Cœur de Montréal · CAParacelsus Elena Klinik Kassel · DEUniversity of Cagliari · ITAntwerp University Hospital · BECalifornia Center for Sleep Disorders · USInserm · FRJohns Hopkins University · USMayo Clinic · USNational Institute of Neurological Disorders and Stroke · USNational Institute on Aging · USNuffield Orthopaedic Centre · GBSorbonne Université · FRUniversité de Montpellier · FRUniversité de Nîmes · FRUniversité du Québec à Montréal · CA
Funding
Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4MIntramural NIH HHS ZIA NS003154
Abstract
Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (p
Indexed as
Lewy Body DiseaseREM Sleep Behavior DisorderSynucleinopathiesHLA AntigensHLA-DRB1 ChainsHumansHLA AntigensHLA-DRB1 Chains
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