Evidence map›Paper›PMID 37401194›Full record

ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2023

Effects of head-down tilt on optic nerve sheath diameter in healthy subjects.

Jessica J Ustick, Laura P Pardon, Pratik Chettry, Nimesh B Patel, Han Cheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jessica J UstickCollege of Optometry, University of Houston, Houston, Texas, USA.
Laura P PardonCollege of Optometry, University of Houston, Houston, Texas, USA.
Pratik ChettryCollege of Optometry, University of Houston, Houston, Texas, USA.ORCID 0000-0002-5205-7573
Nimesh B PatelCollege of Optometry, University of Houston, Houston, Texas, USA.ORCID 0000-0002-1772-2611
Han ChengCollege of Optometry, University of Houston, Houston, Texas, USA.ORCID 0000-0003-1035-2686
University of Houston · US

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI VALLABH E DAS · 1988 to 2026
$16.4M
The Role of Galectins in Corneal Hem- and LymphangiogenesisR01EY007088 · NEI · TUFTS UNIVERSITY BOSTON · PI PANJWANI, NOORJAHAN · 1987 to 2015
$3.6M
SHORT TERM TRAINING--STUDENTS IN HEALTH PROFESSIONST35EY007088 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FRISHMAN, LAURA J. · 1985 to 2025
$2.3M
FMRI STUDIES;VISUAL EXPERIENCE AND NEURONAL CHANGESF32EY007088 · NEI · MAX PLANCK INST/BIOLOGICAL CYBERNETICS · PI TOLIAS, ANDREAS SAVAS · 2000 to 2003
$116k
NEI NIH HHS F32 EY007088NEI NIH HHS NEI T35EY007088NEI NIH HHS NIH P30 EY007551NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY007088NEI NIH HHS T35 EY007088
6 · The paper itself

Abstract

purposeIntracranial pressure increases in head-down tilt (HDT) body posture. This study evaluated the effect of HDT on the optic nerve sheath diameter (ONSD) in normal subjects.

methodsTwenty six healthy adults (age 28 [4.7] years) participated in seated and 6° HDT visits. For each visit, subjects presented at 11:00 h for baseline seated scans and then maintained a seated or 6° HDT posture from 12:00 to 15:00 h. Three horizontal axial and three vertical axial scans were obtained at 11:00, 12:00 and 15:00 h with a 10 MHz ultrasonography probe on the same eye, randomly chosen per subject. At each time point, horizontal and vertical ONSD (mm) were quantified by averaging three measures taken 3 mm behind the globe.

resultsIn the seated visit, ONSDs were similar across time (p > 0.05), with an overall mean (standard deviation) of 4.71 (0.48) horizontally and 5.08 (0.44) vertically. ONSD was larger vertically than horizontally at each time point (p < 0.001). In the HDT visit, ONSD was significantly enlarged from baseline at 12:00 and 15:00 h (p < 0.001 horizontal and p < 0.05 vertical). Mean (standard error) horizontal ONSD change from baseline was 0.37 (0.07) HDT versus 0.10 (0.05) seated at 12:00 h (p = 0.002) and 0.41 (0.09) HDT versus 0.12 (0.06) seated at 15:00 h (p = 0.002); mean vertical ONSD change was 0.14 (0.07) HDT versus -0.07 (0.04) seated at 12:00 h (p = 0.02) and 0.19 (0.06) HDT versus -0.03 (0.04) seated at 15:00 h (p = 0.01). ONSD change in HDT was similar between 12:00 and 15:00 h (p ≥ 0.30). Changes at 12:00 h correlated with those at 15:00 h for horizontal (r = 0.78, p < 0.001) and vertical ONSD (r = 0.73, p < 0.001).

conclusionThe ONSD increased when body posture transitioned from seated to HDT position without any further change at the end of the 3 h in HDT.

Indexed as

Head-Down TiltOptic NerveAdultHealthy VolunteersHumansUltrasonographyhead-down tiltintracranial pressureophthalmic ultrasoundoptic nerve sheath diametertranslaminar pressure

Identifiers

PMID37401194
PMCPMC10592427
OpenAlexW4383058362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.