Evidence map›Paper›PMID 37400966›Full record

ArticleGut microbes

Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice.

Poonamjot Deol, Paul Ruegger, Geoffrey D Logan, Ali Shawki, Jiang Li, Jonathan D Mitchell, Jacqueline Yu, Varadh Piamthai, Sarah H Radi, Sana Hasnain and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Poonamjot DeolDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Paul RueggerDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Geoffrey D LoganDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Ali ShawkiDivision of Biomedical Sciences, University of California, Riverside, CA, USA.
Jiang LiDivision of Biomedical Sciences, University of California, Riverside, CA, USA.
Jonathan D MitchellDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Jacqueline YuDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Varadh PiamthaiDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Sarah H RadiDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Sana HasnainDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Kamil BorkowskiWest Coast Metabolomics Center, Genome and Biological Sciences Facility, University of California Davis, Davis, CA, USA.
John W NewmanWest Coast Metabolomics Center, Genome and Biological Sciences Facility, University of California Davis, Davis, CA, USA.
Declan F McColeDivision of Biomedical Sciences, University of California, Riverside, CA, USA.
Meera G NairDivision of Biomedical Sciences, University of California, Riverside, CA, USA.
Ansel HsiaoDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
James BornemanDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Frances M SladekDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
University of California, Riverside · USUniversity of California, Davis · USWestern Human Nutrition Research Center · US

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
REGULATION OF LIVER SPECIFIC GENE EXPRESSIONR01DK053892 · NIDDK · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SLADEK, FRANCES M. · 1998 to 2015
$5.3M
Vibrio cholerae antinitrosative stress defenses and gut microbiome interactionR01AI157106 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HSIAO, ANSEL, ZHU, JUN · 2020 to 2024
$4.0M
RELMalpha-expressing macrophages mediate host disease tolerance in mucosal infectionR01AI153195 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI NAIR, MEERA GOH · 2020 to 2024
$3.5M
Balance between HNF4a isoforms in the carbohydrate-lipid metabolic switchR01DK127082 · NIDDK · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SLADEK, FRANCES M. · 2021 to 2025
$2.0M
Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
NIAID NIH HHS R01 AI153195NIAID NIH HHS R01 AI157106NIDDK NIH HHS R01 DK053892NIDDK NIH HHS R01 DK091281NIDDK NIH HHS R01 DK127082NIDDK NIH HHS U24 DK097154NIGMS NIH HHS R35 GM124724
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18:2 omega-6), which must be obtained from the diet, may promote the development of IBD in humans. To demonstrate a causal link between LA and IBD, we show that a high fat diet (HFD) based on soybean oil (SO), which is comprised of ~55% LA, increases susceptibility to colitis in several models, including IBD-susceptible IL10 knockout mice. This effect was not observed with low-LA HFDs derived from genetically modified soybean oil or olive oil. The conventional SO HFD causes classical IBD symptoms including immune dysfunction, increased intestinal epithelial barrier permeability, and disruption of the balance of isoforms from the IBD susceptibility gene Hepatocyte Nuclear Factor 4α (HNF4α). The SO HFD causes gut dysbiosis, including increased abundance of an endogenous adherent invasive

Indexed as

ColitisGastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsDiet, High-FatEndocannabinoidsHumansLinoleic AcidMiceSoybean OilEndocannabinoidsLinoleic AcidSoybean Oiladherent invasive E.Coliepithelial barrier functiongut microbiomeHNF4αIBDmetabolomicsolive oiloxylipinsPUFAssoybean oil

Identifiers

PMID37400966
PMCPMC10321214
OpenAlexW4383058720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.