Evidence map›Paper›PMID 37400918›Full record

ArticleJournal of intensive care2023

Correlation between tissue Doppler-derived left ventricular systolic velocity (S') and left ventricle ejection fraction in sepsis and septic shock: a retrospective cohort study.

Sanchit Chawla, Ryota Sato, Abhijit Duggal, Mahmoud Alwakeel, Daisuke Hasegawa, Dina Alayan, Patrick Collier, Filippo Sanfilippo, Michael Lanspa, Siddharth Dugar

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Article in Journal of intensive care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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7citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sanchit ChawlaDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Ryota SatoDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Abhijit DuggalDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Mahmoud AlwakeelDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Daisuke HasegawaDepartment of Internal Medicine, Mount Sinai Beth Israel, New York, NY, USA.
Dina AlayanDepartment of Medicine, Cleveland Clinic, Cleveland, OH, USA.
Patrick CollierDepartment of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Filippo SanfilippoAnaesthesiology and Intensive Care, University of Catania, Catania, Italy.
Michael LanspaCritical Care Echocardiography Service, Intermountain Medical Center, Murray, UT, USA.
Siddharth DugarDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. Dugars@ccf.org.ORCID http://orcid.org/0000-0002-3243-1417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTissue Doppler-derived left ventricular systolic velocity (mitral S') has shown excellent correlation to left ventricular ejection fraction (LVEF) in non-critically patients. However, their correlation in septic patients remains poorly understood and its impact on mortality is undetermined. We investigated the relationship between mitral S' and LVEF in a large cohort of critically-ill septic patients.

methodsWe conducted a retrospective cohort study between 01/2011 and 12/2020. All adult patients (≥ 18 years) who were admitted to the medical intensive care unit (MICU) with sepsis and septic shock that underwent a transthoracic echocardiogram (TTE) within 72 h were included. Pearson correlation test was used to assess correlation between average mitral S' and LVEF. Pearson correlation was used to assess correlation between average mitral S' and LVEF. We also assessed the association between mitral S', LVEF and 28-day mortality.

results2519 patients met the inclusion criteria. The study population included 1216 (48.3%) males with a median age of 64 (IQR: 53-73), and a median APACHE III score of 85 (IQR: 67, 108). The median septal, lateral, and average mitral S' were 8 cm/s (IQR): 6.0, 10.0], 9 cm/s (IQR: 6.0, 10.0), and 8.5 cm/s (IQR: 6.5, 10.5), respectively. Mitral S' was noted to have moderate correlation with LVEF (r = 0.46). In multivariable logistic regression analysis, average mitral S' was associated with an increase in both 28-day ICU and in-hospital mortality with odds ratio (OR) 1.04 (95% CI 1.01-1.08, p = 0.02) and OR 1.04 (95% CI 1.01-1.07, p = 0.02), respectively.

conclusionsEven though mitral S' and LVEF may be related, they are not exchangeable and were only found to have moderate correlation in this study. LVEF is U-shaped, while mitral S' has a linear relation with 28-day ICU mortality. An increase in average mitral S' was associated with higher 28-day mortality.

Indexed as

CorrelationICU mortalityLeft ventricle systolic dysfunctionMitral atrioventricular planeSepsisShockTissue Doppler Imaging

Identifiers

PMID37400918
PMCPMC10316553

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