ArticleBMC public health2023
Association between night shift work and NAFLD: a prospective analysis of 281,280 UK Biobank participants.
Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shift work and metabolic dysfunction-associated steatotic liver disease: a systematic review of observational studies.International archives of occupational and environmental health · 2025Pooled it
- Changes in Muscle Mass and the Risk of Liver-Related Events: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Circadian and behavioral timing in MASLD: a systematic review of human observational studies.EClinicalMedicine · 2026Article
- Occupational-circadian disruption and physical inactivity conjointly amplify fatty liver risk: based on liver ultrasound transient elastography.International journal of occupational medicine and environmental health · 2026Article
- Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies.The Journal of clinical endocrinology and metabolism · 2026Article
- Deep learning-based physiological risk stratification in night-shift hospital workers.Scientific reports · 2026Article
- Association between occupational noise exposure and metabolic dysfunction-associated fatty liver disease: the mediating role of body mass index in automotive manufacturing workers.Frontiers in public health · 2026Article
- Joint association of cumulative workplace environmental exposures and shift work with long-term work-limiting health conditions: a prospective cohort study from the UK Biobank.BMJ public health · 2026Article
- Association of Shift Work, Health Behaviors, and Socioeconomic Status with Diabesity in over 53,000 Spanish Employees.Journal of clinical medicine · 2025Article
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Risk factors of metabolic dysfunction-associated fatty liver disease in Chinese nurses: an ambispective cohort study.Frontiers in public health · 2025Article
- Potential bidirectional communication between the liver and the central circadian clock in MASLD.npj metabolic health and disease · 2025Review
- Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy.Frontiers in endocrinology · 2025Review
- Association of shift work with metabolic dysfunction-associated fatty liver disease among subway workers.Frontiers in public health · 2025Article
- Circadian Deregulation: Back Facing the Sun Toward Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development.Nutrients · 2024Review
- Liver-gut axis signaling regulates circadian energy metabolism in shift workers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer.Hepatoma research · 2024Article
- Associations of ambient air pollution and lifestyle with the risk of NAFLD: a population-based cohort study.BMC public health · 2024Article
- Shift work and non-alcoholic fatty liver disease in young, healthy workers.Scientific reports · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThis study aimed to investigate the association between night shift work and the risk of nonalcoholic fatty liver disease (NAFLD).
methodsWe conducted a prospective analysis of 281,280 UK Biobank participants. Cox proportional hazards models were used to estimate the association of night shift work with incident NAFLD. Polygenic risk score analyses were performed to assess whether a genetic predisposition to NAFLD modified the association.
resultsDuring a median follow-up of 12.1 years (3,373,964 person-years), 2,555 incident NAFLD cases were identified. Compared with workers who never/rarely worked night shifts, those who worked some night shifts or usual/permanent night shifts were 1.12 (95% CI: 0.96-1.31) and 1.27 (95% CI: 1.08-1.48) times more likely to develop NAFLD, respectively. Among the 75,059 participants who had reports on lifetime experience of night shift work, those with a longer duration, a higher frequency, more consecutive night shifts and a longer length per shift all showed higher risks of incident NAFLD. Further analyses showed that the association between night shift work and incident NAFLD was not modified by a genetic predisposition to NAFLD.
conclusionsNight shift work was associated with increased risks of incident NAFLD.
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