Evidence map›Paper›PMID 37400751›Full record

ArticleBMC cancer2023

A simple and available measurement of onco-sEV dsDNA to protein ratio as a potential tumor marker.

Yifan Sun, Miao Li, Xiaoshan Zhang, Dongjie Xu, Jie Wu, Xinrui Gu, Adeel Khan, Han Shen, Zhiyang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yifan Sun *Department of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.
Miao Li *Department of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.
Xiaoshan ZhangCollege of Life Science, Yangtze University, Jingzhou, China.
Dongjie XuCollege of Life Science, Yangtze University, Jingzhou, China.
Jie WuDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.
Xinrui GuDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Adeel KhanState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, National Demonstration Center for Experimental Biomedical Engineering Education (Southeast University, Southeast University, Nanjing, China.
Han ShenDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China. shenhan10366@sina.com.
Zhiyang LiDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China. lizhiyangcn@qq.com.
Nanjing Drum Tower Hospital · CNYangtze University · CNSoutheast University · CN

Funding

Doctoral Program of Entrepreneurship and Innovation of Jiangsu Province JSSCBS20211509Jiangsu Provincial Key Research and Development Program BE2019603, BE2019761, BE2020768, and BE2022692National Natural Science Foundation of China 61971216National Natural Science Foundation of China 82103578
6 · The paper itself

Abstract

backgroundSmall extracellular vesicles (sEVs) have great potential as new biomarkers in liquid biopsy. However, due to the limitations of sEVs extraction and component analysis procedures, further clinical applications of sEVs are hampered. Carcinoembryonic antigen (CEA) is a commonly used broad-spectrum tumor marker that is strongly expressed in a variety of malignancies.

resultsIn this study, CEA

conclusionsThis study demonstrates that the dsDPr of CEA

Indexed as

Extracellular VesiclesNucleic AcidsBiomarkers, TumorCarcinoembryonic AntigenDNAHumansBiomarkers, TumorCarcinoembryonic AntigenDNANucleic AcidsDouble-stranded DNANucleic acid to protein ratioSmall extracellular vesiclesTumor diagnosis

Identifiers

PMID37400751
PMCPMC10316596
OpenAlexW4382939675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.