ArticleNature biomedical engineering2023
Simultaneous quantitative imaging of two PET radiotracers via the detection of positron-electron annihilation and prompt gamma emissions.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- Membrane-bound TRAIL-armoring augments CAR-T cells in mesothelin-positive solid malignancies.Journal for immunotherapy of cancer · 2026Article
- Separation of simultaneously acquired [European journal of nuclear medicine and molecular imaging · 2026Article
- Improved random coincidence estimation including triple coincidence detection in PET.Frontiers in nuclear medicine · 2026Article
- Practical considerations for clinical translation of PET imaging of adoptive cell therapies.Npj imaging · 2025Review
- Radiolabeling lipoproteins to study and manage disease.European journal of nuclear medicine and molecular imaging · 2025Review
- Combining Dopamine Transporter and Amyloid PET Tracer: A Preclinical Study on Dual-Target Imaging.Molecular imaging and biology · 2025Article
- Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025Review
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- A Quantitative Particle Identification (QPID) spectral autoradiography system.Communications engineering · 2025Article
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- Targeted K-Edge Nanoprobes From Praseodymium and Hafnium for Ratiometric Tracking of Dual Biomarkers using Spectral Photon Counting CT.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Comparative analysis of positron emitters for theranostic applications based on small bioconjugates highlightingEJNMMI physics · 2024Article
- Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis.Nature communications · 2024Article
- A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy.IEEE journal of solid-state circuits · 2024Article
- uPAR Immuno-PET in Pancreatic Cancer, Aging, and Chemotherapy-Induced Senescence.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- A comprehensive review on Compton camera image reconstruction: from principles to AI innovations.Biomedical engineering letters · 2024Review
- Quantum Entanglement Filtering: A PET feasibility study in imaging dual-positron and prompt gamma emission via Monte Carlo simulation.IEEE transactions on radiation and plasma medical sciences · 2024Article
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Authors and funding
11 authors.
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Abstract
In conventional positron emission tomography (PET), only one radiotracer can be imaged at a time, because all PET isotopes produce the same two 511 keV annihilation photons. Here we describe an image reconstruction method for the simultaneous in vivo imaging of two PET tracers and thereby the independent quantification of two molecular signals. This method of multiplexed PET imaging leverages the 350-700 keV range to maximize the capture of 511 keV annihilation photons and prompt γ-ray emission in the same energy window, hence eliminating the need for energy discrimination during reconstruction or for signal separation beforehand. We used multiplexed PET to track, in mice with subcutaneous tumours, the biodistributions of intravenously injected [
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