ArticleBiomechanics and modeling in mechanobiology2023
Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI.
Article in Biomechanics and modeling in mechanobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 23 citations in OpenAlex.
- Incorporating Torsion Into 3D Geometric Reconstruction of Left-Ventricle From 2D Echocardiography and Its Impact on Hemodynamics.International journal for numerical methods in biomedical engineering · 2026Article
- Effect of the Mitral Valve on the Intra Ventricular Hemodynamics.International journal for numerical methods in biomedical engineering · 2026Article
- Serial echocardiography-based diagnosis of a left atrial thrombus mimicking myxoma in severe mitral regurgitation.European heart journal. Case reports · 2026Article
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations.International journal for numerical methods in biomedical engineering · 2025Article
- Image-based, whole-system hemodynamic modeling of mitral regurgitation and its impact on the right ventricular function.Frontiers in cardiovascular medicine · 2025Article
- Image-Based Computational Fluid Dynamics to Compare Two Repair Techniques for Mitral Valve Prolapse.Annals of biomedical engineering · 2024Article
- Application of Real-Time Palm Imaging with Nelder-Mead Particle Swarm Optimization/Regression Algorithms for Non-Contact Blood Pressure Detection.Biomimetics (Basel, Switzerland) · 2024Article
- lifex-ep: a robust and efficient software for cardiac electrophysiology simulations.BMC bioinformatics · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this work, we performed a computational image-based study of blood dynamics in the whole left heart, both in a healthy subject and in a patient with mitral valve regurgitation. We elaborated multi-series cine-MRI with the aim of reconstructing the geometry and the corresponding motion of left ventricle, left atrium, mitral and aortic valves, and aortic root of the subjects. This allowed us to prescribe such motion to computational blood dynamics simulations where, for the first time, the whole left heart motion of the subject is considered, allowing us to obtain reliable subject-specific information. The final aim is to investigate and compare between the subjects the occurrence of turbulence and the risk of hemolysis and of thrombi formation. In particular, we modeled blood with the Navier-Stokes equations in the arbitrary Lagrangian-Eulerian framework, with a large eddy simulation model to describe the transition to turbulence and a resistive method to manage the valve dynamics, and we used a finite element discretization implemented in an in-house code for the numerical solution.
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