Evidence map›Paper›PMID 37400558›Full record

ReviewNature methods2023

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions.

Bálint Mészáros, András Hatos, Nicolas Palopoli, Federica Quaglia, Edoardo Salladini, Kim Van Roey, Haribabu Arthanari, Zsuzsanna Dosztányi, Isabella C Felli, Patrick D Fischer and 16 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Best practices for the manual curation of intrinsically disordered proteins in DisProt.Database : the journal of biological databases and curation · 2024
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Bálint MészárosStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0919-4449
András Hatos *Department of Biomedical Sciences, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-9224-9820
Nicolas Palopoli *Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires, Argentina.
Federica Quaglia *Department of Biomedical Sciences, University of Padova, Padova, Italy.
Edoardo Salladini *Department of Biomedical Sciences, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-5152-5953
Kim Van Roey *Interuniversity Institute of Bioinformatics in Brussels, ULB-VUB, Brussels, Belgium.
Haribabu ArthanariHarvard Medical School (HMS), Boston, MA, USA.ORCID http://orcid.org/0000-0002-7281-1289
Zsuzsanna DosztányiDepartment of Biochemistry, Eötvös Loránd University, Budapest, Hungary.
Isabella C FelliDepartment of Chemistry 'Ugo Schiff' and Magnetic Resonance Center, University of Florence, Sesto Fiorentino (Florence), Italy.
Patrick D FischerHarvard Medical School (HMS), Boston, MA, USA.
Jeffrey C HochDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA.
Cy M JeffriesEuropean Molecular Biology Laboratory (EMBL), Hamburg Unit, c/o Deutsches Elektronen-Synchrotron, Hamburg, Germany.ORCID http://orcid.org/0000-0002-8718-7343
Sonia LonghiLaboratory Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), Marseille, France.ORCID http://orcid.org/0000-0002-6829-6771
Emiliano MaianiCancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1432-5394
Sandra OrchardEuropean Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, UK.ORCID http://orcid.org/0000-0002-8878-3972
Rita PancsaInstitute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
Elena PapaleoCancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Roberta PierattelliDepartment of Chemistry 'Ugo Schiff' and Magnetic Resonance Center, University of Florence, Sesto Fiorentino (Florence), Italy.ORCID http://orcid.org/0000-0001-7755-0885
Damiano PiovesanDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Iva PritisanacHospital for Sick Children, Toronto, Ontario, Canada.
Luiggi TenorioDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Thibault ViennetHarvard Medical School (HMS), Boston, MA, USA.ORCID http://orcid.org/0000-0001-5349-0179
Peter TompaInstitute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.ORCID http://orcid.org/0000-0001-8042-9939
Wim VrankenInteruniversity Institute of Bioinformatics in Brussels, ULB-VUB, Brussels, Belgium.ORCID http://orcid.org/0000-0001-7470-4324
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0003-4525-7793
Norman E DaveyDivision Of Cancer Biology, Institute of Cancer Research, Chester Beatty Laboratories, Chelsea, London, UK. norman.davey@icr.ac.uk.ORCID http://orcid.org/0000-0001-6988-4850

Funding

The BMRB as an evolving resource for biomolecular structure-function researchR01GM109046 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HOCH, JEFFREY C · 2014 to 2022
$6.6M
Cancer Research UK 28159NIGMS NIH HHS R01 GM109046
6 · The paper itself

Abstract

An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.

Indexed as

Intrinsically Disordered ProteinsProtein ConformationIntrinsically Disordered Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.