Evidence map›Paper›PMID 37400551›Full record

ArticleCommunications biology2023

RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.

Vincent Oei, Linda Shyue Huey Chuang, Junichi Matsuo, Supriya Srivastava, Ming Teh, Yoshiaki Ito

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vincent Oei *Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-0708-3884
Linda Shyue Huey Chuang *Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9078-9532
Junichi MatsuoCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-2378-2370
Supriya SrivastavaDepartment of Medicine, National University of Singapore, Singapore, Singapore.
Ming TehDepartment of Pathology, National University of Singapore, Singapore, Singapore.
Yoshiaki ItoCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. yoshi_ito@nus.edu.sg.ORCID 0000-0002-9037-1184
National University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MYC is one of the most commonly dysregulated proto-oncogenes in cancer. MYC promotes cancer initiation and maintenance by regulating multiple biological processes, such as proliferation and stem cell function. Here, we show that developmental regulator RUNX3 targets MYC protein for rapid degradation through the glycogen synthase kinase-3 beta-F-box/WD repeat-containing protein 7 (GSK3β-FBXW7) proteolytic pathway. The evolutionarily conserved Runt domain of RUNX3 interacts directly with the basic helix-loop-helix leucine zipper of MYC, resulting in the disruption of MYC/MAX and MYC/MIZ-1 interactions, enhanced GSK3β-mediated phosphorylation of MYC protein at threonine-58 and its subsequent degradation via the ubiquitin-proteasomal pathway. We therefore uncover a previously unknown mode of MYC destabilization by RUNX3 and provide an explanation as to why RUNX3 inhibits early-stage cancer development in gastrointestinal and lung mouse cancer models.

Indexed as

Cell NucleusCore Binding Factor Alpha 3 SubunitLung NeoplasmsAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell Line, TumorF-Box-WD Repeat-Containing Protein 7Glycogen Synthase Kinase 3 betaMiceProteolysisProto-Oncogene Proteins c-mycBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCore Binding Factor Alpha 3 SubunitF-Box-WD Repeat-Containing Protein 7Glycogen Synthase Kinase 3 betaMax protein, mouseMyc protein, mouseProto-Oncogene Proteins c-mycRunx3 protein, mouse

Identifiers

PMID37400551
PMCPMC10317990
OpenAlexW4382931730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.